A comparative study of the role of crocin and sitagliptin in attenuation of STZ-induced diabetes mellitus and the associated inflammatory and apoptotic changes in pancreatic β-islets

In conclusion, crocin reduced blood glucose level mainly via reduction of oxidative burden, modulation of apoptotic pathway and attenuation of pancreatic inflammation.
Source: Environmental Toxicology and Pharmacology - Category: Environmental Health Source Type: research

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Publication date: Available online 16 October 2019Source: Journal of Integrative MedicineAuthor(s): Olubukola Titilope Oyebode, Foluso Olayemi Ogunbiyi, Olufunso Olabode OlorunsogoAbstractObjectiveSeveral pathologies arise from the inappropriate opening of the mitochondrial permeability transition (mPT) pore. In this regard, inhibition of mPT pore represents a cytoprotective approach to preserve mitochondrial function for treatment of diseases characterized by excessive tissue wastage such as diabetes mellitus. The aim of this study, therefore, was to study the effects of fractions of Ficus mucoso, a medicinal plant used i...
Source: Journal of Integrative Medicine - Category: Complementary Medicine Source Type: research
Authors: Andreeva-Gateva PA, Mihaleva ID, Dimova II Abstract Diabetes mellitus and cardiovascular diseases are part of the metabolic syndrome and share similar risk factors, including obesity, arterial hypertension, and dyslipidemia. Atherosclerosis and insulin resistance contribute to the development of the diseases, and subclinical inflammation is observed in both conditions. There are many proofs about the connection between epigenetic factors and different diseases, including diabetes and cardiovascular diseases. Interestingly, recent studies show that at least some anti-diabetic drugs, as well as blockers of t...
Source: Postgraduate Medicine - Category: Internal Medicine Tags: Postgrad Med Source Type: research
Abstract PMID: 31612806 [PubMed - in process]
Source: Current Medicinal Chemistry - Category: Chemistry Authors: Tags: Curr Med Chem Source Type: research
Publication date: September 2019Source: Chinese Medical Sciences Journal, Volume 34, Issue 3Author(s): Qiang Chen, Liwei Zhang, Dangsheng Huang, Chunhong Zhang, Qiushuang Wang, Dong Shen, Minjun Xiong, Feifei YangObjectiveTo evaluate the instant effects and five-year clinical outcomes of coronary artery disease patients complicated with diabetes mellitus after StentBoost-optimized percutaneous coronary intervention (PCI).MethodsFrom March 2009 to July 2010, 184 patients undergoing PCI at our hospital were found stent underexpansion or malapposition by StentBoost after stents implantation and were divided into the diabetic ...
Source: Chinese Medical Sciences Journal - Category: General Medicine Source Type: research
The sleeve gastrectomy (SG), Roux-en-Y gastric bypass (RYGB), and single anastomosis duodenal-ileal bypass with SG (SADI-S) are recognized bariatric procedures. A comparison has never been made between these three procedures and especially in different body mass index (BMI) categories.
Source: Surgery for Obesity and Related Diseases - Category: Surgery Authors: Tags: Original articles Source Type: research
To investigate the association of VitD with GDM, and examine the potential modifying effect of prepregnancy BMI in Chinese pregnant women.
Source: Clinical Nutrition - Category: Nutrition Authors: Tags: Original article Source Type: research
Publication date: 15 October 2019Source: Cell Reports, Volume 29, Issue 3Author(s): Yongxu Zhao, Zhuanghui Feng, Qiurong DingSummaryThis Matters Arising Response paper addresses the Hoch et al. (2019) Matters Arising paper published concurrently in this issue of Cell Reports. The genetic study in humans revealed a strong association of DNA variants in the SLC16A11 coding region with type 2 diabetes mellitus (T2DM). However, how these T2D variants affect the function of SLC16A11 remains controversial. In Zhao et al. (2019), with studies using genetic knockout mouse models and in vivo gene reconstitution exper...
Source: Cell Reports - Category: Cytology Source Type: research
Despite the increasing burden of diabetes in Uganda, little is known about the quality of type 2 diabetes mellitus (T2DM) care especially in rural areas. Poor quality of care is a serious limitation to the con...
Source: BMC Health Services Research - Category: General Medicine Authors: Tags: Research article Source Type: research
This study aims to evaluate firstly the experiences, barriers and facilitators to app usage a...
Source: Diabetology and Metabolic Syndrome - Category: Endocrinology Authors: Tags: Research Source Type: research
Elderly people with type 2 diabetes mellitus (T2DM) have an increased risk of diabetes-related microvascular and macrovascular complications, thus diabetic patients with a functioning gastrointestinal tract bu...
Source: Nutrition and Metabolism - Category: Nutrition Authors: Tags: Research Source Type: research
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