Pleiotropic Meta-Analysis of Cognition, Education, and Schizophrenia Differentiates Roles of Early Neurodevelopmental and Adult Synaptic Pathways

Susceptibility to schizophrenia is inversely correlated with general cognitive ability at both the phenotypic and the genetic level. Paradoxically, a modest but consistent positive genetic correlation has been reported between schizophrenia and educational attainment, despite the strong positive genetic correlation between cognitive ability and educational attainment. Here we leverage published genome-wide association studies (GWASs) in cognitive ability, education, and schizophrenia to parse biological mechanisms underlying these results.
Source: The American Journal of Human Genetics - Category: Genetics & Stem Cells Authors: Tags: Article Source Type: research

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Authors: Kane JM, Correll CU Abstract Acute and long-term objectives must be linked early in the treatment of schizophrenia. Maintenance therapy is pivotal in relapse prevention. Relapses are serious events that alter disease trajectory and are most often related to nonadherence. Patients with schizophrenia have a substantial risk of relapse, especially when they are nonadherent to antipsychotics. Because relapses are accompanied by structural brain changes, worsening symptoms, and increased treatment resistance when medication is resumed, clinicians must monitor nonadherence and offer strategies to avoid or improv...
Source: Journal of Clinical Psychiatry - Category: Psychiatry Tags: J Clin Psychiatry Source Type: research
CONCLUSIONS: The current study highlights that early prevention of periodontal disease in individuals with schizophrenia is crucial. Along with paying more attention to the development of periodontal disease, assessing oral health regularly, helping with oral hygiene, and lowering consumption of sugary drinks and tobacco, emphasis should also be given by physicians to reduce the prescription of antipsychotics to the extent possible under efficacious pharmacotherapy for schizophrenia. PMID: 31526409 [PubMed - as supplied by publisher]
Source: Epidemiology and Psychiatric Sciences - Category: Psychiatry Tags: Epidemiol Psychiatr Sci Source Type: research
ConclusionOur panoramic meta-overview suggests that exercise can be an effective adjunctive treatment for improving symptoms across a broad range of mental disorders.
Source: Sports Medicine - Category: Sports Medicine Source Type: research
This study was aimed at testing explanatory models of negative and positive experiences of caregiving considering the role of the caregiver’s perceptions of difficulties, satisfaction, and coping. A convenience sample of 159 informal caregivers of patients with schizophrenia was used in this study. Different variables were considered: (1) perception of difficulties (Caregiver’s Assessment of Difficulties Index); (2) perception of satisfaction (Caregiver’s Assessment of Satisfaction Index); (3) perception of coping (Caregiver’s Assessment of Managing Index); and (4) the experience of ...
Source: International Journal of Environmental Research and Public Health - Category: Environmental Health Authors: Tags: Article Source Type: research
by Justin D. Rasmussen, Bernard Kakuhikire, Charles Baguma, Scholastic Ashaba, Christine E. Cooper-Vince, Jessica M. Perkins, David R. Bangsberg, Alexander C. Tsai BackgroundMental illness stigma is a fundamental barrier to improving mental health worldwide, but little is known about how to durably reduce it. Understanding of mental illness as a treatable medical condition may influence stigmatizing beliefs, but available evidence to inform this hypothesis has been derived solely from high-income countries. We embedded a randomized survey experiment within a whole-population cohort study in rural southwestern Uganda to ass...
Source: PLoS Medicine - Category: Internal Medicine Authors: Source Type: research
So now, according to the Washington Post, the Trump Administration is “…considering a controversial proposal to study whether mass shootings could be prevented by monitoring mentally ill people for small changes that might foretell violence.”1 As a psychiatrist, I keep wondering how many times the White House will scapegoat those with psychiatric illnesses rather than looking at the scientific data on mass shooters. To understand the problem, consider the case of “Tyler” (a composite of many mass shooter profiles). Tyler is a 19-year-old, single, unemployed high school dropout. He was wo...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Criminal Justice Mental Health and Wellness Stigma Violence and Aggression extreme risk protection order mass shooting Mental Illness red flag law Source Type: blogs
Conclusions: Inter-rater and test-retest agreement exhibited satisfactory ICC levels above 0.70. The Norwegian version of the DIEPSS is a reliable instrument for the assessment of drug-induced EPSs. PMID: 31532276 [PubMed - as supplied by publisher]
Source: Nordic Journal of Psychiatry - Category: Psychiatry Tags: Nord J Psychiatry Source Type: research
Authors: Marques JG, Pires S PMID: 31529808 [PubMed - in process]
Source: The Primary Care Companion for CNS Disorders - Category: Primary Care Tags: Prim Care Companion CNS Disord Source Type: research
Abstract Chromosome conformation capture methods have revealed the dynamics of genome architecture which is spatially organized into topologically associated domains, with gene regulation mediated by enhancer-promoter pairs in chromatin space. New evidence shows that endogenous hormones and several xenobiotics act within circumscribed topological domains of the spatial genome, impacting subsets of the chromatin contacts of enhancer-gene promoter pairs in cis and trans Results from the National Institutes of Health-funded PsychENCODE project and the study of chromatin remodeling complexes have converged to provide ...
Source: Pharmacological Reviews - Category: Drugs & Pharmacology Authors: Tags: Pharmacol Rev Source Type: research
 Chrisa Hickey’s journey into mental health advocacy started when her son, Tim, was diagnosed with very early onset schizophrenia after being admitted to a psychiatric hospital for the first time at the age of 11.  He had been showing symptoms for years and had received a half dozen different diagnoses. His family was desperately looking for answers. Tim’s illness took a toll on the entire family, which was only exacerbated by the lack of information and resources available to them.  In America, fewer than 100 children per year are diagnosed with very early onset schizophrenia. Chrisa had to find ...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Bipolar Children and Teens Depression Family General Mental Health and Wellness Parenting Podcast Psychiatry Psychology Schizophrenia The Psych Central Show Source Type: blogs
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