LncRNA GAS5 overexpression downregulates IL-18 and induces the apoptosis of fibroblast-like synoviocytes

ConclusionsTherefore, GAS5 overexpression may improve RA by downregulating IL-18 and inducing the apoptosis of fibroblast-like synoviocytes.Key points•The present study mainly showed that overexpression of GAS5 may assist the treatment of RA.•The mechanism of GAS5 for the treatment of RA involves the downregulating inflammatory IL-18 and mediating the apoptosis of fibroblast-like synoviocytes.•GAS5 and IL-8 were correlated in RA patients but not in healthy controls.
Source: Clinical Rheumatology - Category: Rheumatology Source Type: research