Impact of different antimycotics on cytokine levels in an in vitro aspergillosis model in human whole blood

ConclusionsOur data indicate significant differences in the immunomodulatory potency of different antimycotics. While fluconazole had the highest anti-inflammatory potential, conventional amphotericin even increased cytokine release. This preliminary information might have clinical implication, since cytokine dysregulation plays a major role in the pathogenesis and outcome of fungal infections. Clinical studies are warranted to confirm our findings.
Source: Infection - Category: Infectious Diseases Source Type: research