Comparative study of the efficacy and pharmacokinetics of reduning injection and atomization inhalation

Publication date: October 2019Source: Biomedicine & Pharmacotherapy, Volume 118Author(s): Guangping Zhang, Yingfei Li, Tengfei Chen, Yunhang Gao, Jing Sun, Wei Yang, Ling Song, Ping Su, Meng Ma, Zhongxiu Zhang, Haijing Zhang, Yifei Yang, Han Li, Zuguang Ye, Hongping HouAbstractThe effects of Reduning injection and nebulized inhalation for treating upper respiratory tract infections were compared, including anti-bacterial, anti-viral, anti-inflammatory, anti-pyretic, anti-tussive, and anti-phlegm. Using chlorogenic acid, cryptochlorogenic acid, neochlorogenic acid, and geniposide as the index components, the pharmacokinetics and tissue distributions were compared. Influenza virus PR8-infected mice in the Reduning groups showed significantly reduced mortality and prolonged survival time. The white blood cell count was significantly reduced in the 20- and 10-min groups. Inhalation significantly decreased the temperature from 2 h in the 20- and 10-min groups. Inhalation significantly reduced the cough rate but not cough latency. Phenol red excretion was significantly increased in all Reduning groups. The elimination half-life of geniposide after inhalation in male and female rats was 2.05–5.28 and 4.03–10.4 h, respectively, which was much greater than after injection. Regarding tissue distribution, the injection dose (2 mL/kg) was 50 times the inhalation dose, and maximum serum concentration (Cmax) and AUCINF_obs of the four components in the trachea and lung were 0.95â...
Source: Biomedicine and Pharmacotherapy - Category: Drugs & Pharmacology Source Type: research