Effects of pre-operative recreational smoked cannabis use on opioid consumption following inflammatory bowel disease surgery: A historical cohort study

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Source: European Journal of Anaesthesiology - Category: Anesthesiology Tags: Correspondence Source Type: research

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ConclusionsTreatment of complex recurrent cryptoglandular fistula-in-ano by surgery combined to autologous bone marrow –derived MSCs and PRP injection seems safe in selected patients, allowing long-term healing. This procedure seems promising but further evaluation by clinical trials is warranted.
Source: International Journal of Colorectal Disease - Category: Gastroenterology Source Type: research
Colonoscopy is essential for the diagnosis of many diseases, such as colorectal cancer, colorectal polyps and ulcerative colitis. Nevertheless, for the severe pain caused by colonoscopy, this examination is poorly tolerated. For people who have a very limit tolerance to anesthesia, it is important to find a method to ease their pain. Previous research found that music can reduce anxiety and pain during colonoscopy. The present study aimed to clarify the mechanism.
Source: Gastrointestinal Endoscopy - Category: Gastroenterology Authors: Tags: Saturday abstract Source Type: research
AbstractPerianal fistulas and abscesses may be cryptogenetic or associated with inflammatory bowel disease (IBD), specifically Crohn ’s disease. Proper identification and classification of these lesions are paramount for correct therapeutic management. Current diagnostic modalities include MRI (magnetic resonance imaging), EUS (endoscopic ultrasound), EUA (exam under anaesthesia) and recently, transperineal ultrasound (TPUS). T he latter has been proposed as a noninvasive, easily available and cost-effective technique to diagnose, assess and follow up perianal disease particularly in IBD patients. This pictorial revi...
Source: Journal of Ultrasound - Category: Radiology Source Type: research
Conclusion The impact of sepsis on the gut is manifold, e.g., sepsis mediated alteration of the gut-blood barrier and increase in the intestinal permeability, which may correlate with the phenomena of bacterial translocation and lymphatic activation (“toxic-lymph”). Systemic consequences of sepsis are widespread and concern to the coagulative system, the microbiome as well as enzymes, such as pancreatic proteases, MMPs and IAPs. Nevertheless, the therapeutic approaches for modulating the mucosal immune system are still rarely effective in daily routine. Recent published studies showing that treatment with FMT,...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Vinay Kumar1, Workineh Torben2, Joshua Mansfield3, Xavier Alvarez3, Curtis Vande Stouwe4, Jian Li5, Siddappa N. Byrareddy6, Peter J. Didier3, Bapi Pahar3, Patricia E. Molina4,7 and Mahesh Mohan3* 1Nektar Therapeutics, South San Francisco, CA, United States 2Department of Biological Sciences, LSU, Alexandria, LA, United States 3Division of Comparative Pathology, Tulane National Primate Research Center, Covington, LA, United States 4Department of Physiology, LSUHSC, New Orleans, LA, United States 5Department of Global Biostatistics and Data Science, Tulane University School of Public Health and Tropical Medicine, ...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Kristina Kuhbandner1, Anna Hammer1, Stefanie Haase1, Elisa Terbrack1, Alana Hoffmann2, Angela Schippers3, Norbert Wagner3, Rehana Z. Hussain4, William A. Miller-Little4, Andrew Y. Koh5, Joshua S. Stoolman6, Benjamin M. Segal6, Ralf A. Linker7† and Olaf Stüve4,8*† 1Department of Neurology, University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nuremberg, Erlangen, Germany 2Department of Molecular Neurology, University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nuremberg, Erlangen, Germany 3Department of Pediatrics, University Hospital RWTH Aachen, Aachen, Germany 4...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Geng-Hong Xia1†, Chao You1,2†, Xu-Xuan Gao1, Xiu-Li Zeng1, Jia-Jia Zhu1, Kai-Yu Xu3, Chu-Hong Tan1, Ruo-Ting Xu1, Qi-Heng Wu1, Hong-Wei Zhou3, Yan He4*‡ and Jia Yin1*‡ 1Department of Neurology, Nanfang Hospital, Southern Medical University, Guangzhou, China 2Department of Neurology, The First People's Hospital of Zunyi, Zunyi, China 3State Key Laboratory of Organ Failure Research, Division of Laboratory Medicine, Zhujiang Hospital, Southern Medical University, Guangzhou, China 4Microbiome Medicine Center, Division of Laboratory Medicine, Zhujiang Hospital, Southern Medical Univ...
Source: Frontiers in Neurology - Category: Neurology Source Type: research
In this study, we evaluated the effect of auranofin on the radiosensitivity of intestinal epithelial cells. The treatment with a combination of 1 μM auranofin and 5 Gy ionizing radiation showed clear additive effects on caspase 3 cleavage and apoptotic DNA fragmentation in IEC-6 cells, and auranofin administration significantly aggravated the radiation-induced intestinal injury in mice. Auranofin treatment also resulted in the activation of the unfolded protein response and in the inhibition of thioredoxin reductase, which is a key component of the cellular antioxidant system. Pre-treatment with N-acetyl cysteine, a wel...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
Michio Kawano1, Masaya Miyoshi1 and Tadaaki Miyazaki2* 1Milk Science Research Institute, Megmilk Snow Brand Co. Ltd., Saitama, Japan 2Department of Probiotics Immunology, Institute for Genetic Medicine, Hokkaido University, Hokkaido, Japan Lactobacillus helveticus SBT2171 (LH2171) has been reported to ameliorate the development of autoimmune diseases, such as collagen-induced arthritis and experimental autoimmune encephalitis in mice and inhibit interleukin (IL)-6 production in antigen-presenting cells in vitro. Regulation of cytokine production by antigen-presenting cells might be critical for the anti-inflamma...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
This study was carried out in accordance with the recommendations of the Case Western Reserve University IACUC committee. The protocol was approved by the Case Western Reserve University IACUC committee. Author Contributions LRD and DW helped design research studies, analyze data and write the manuscript. ZL, RL, and ND conducted experiments, acquired and analyzed data, and assisted with manuscript preparation. LDM conducted experiments and analyzed data. FC assisted with research design. Funding This work was supported by the NIH P30CA043703, K1CA113838, and R01DK081395. Conflict of Interest Statement The authors de...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
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