Complex effects of continuous vasopressor infusion on fluid responsiveness during liver resection: A randomised controlled trial

CONCLUSION Continuous administration of phenylephrine increased fluid responsiveness during liver resection, suggesting complex effects of continuous vasopressor infusion involving changes in cardiac preload and afterload. TRIAL REGISTRATION UMIN000011024.
Source: European Journal of Anaesthesiology - Category: Anesthesiology Tags: Pharmacology Source Type: research

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In conclusion, the impaired in situ activity of RyR2 may also account for the poor overall cardiac outcome reported in MetS patients; hence, the SERCA pump and RyR2 are both attractive potential targets for future therapies. Introduction Metabolic syndrome (MetS) is a cluster of biochemical and physiological risk factors for cardiovascular disease and diabetes mellitus type 2 (DM2); it represents a severe public health problem around the world (Alberti et al., 2009). Risk factors for MetS include obesity (particularly central obesity), elevated triglyceride (TG) levels, low high-density lipoprotein cholesterol (HDL...
Source: Frontiers in Physiology - Category: Physiology Source Type: research
Conclusion: These findings limit the possible roles of gene transcriptional changes in previously reported age-dependent pro-arrhythmic electrophysiologial changes observed in Pgc-1β-/- atria to an altered Ca2+-ATPase (Atp2a2) expression. This directly parallels previously reported arrhythmic mechanism associated with p21-activated kinase type 1 deficiency. This could add to contributions from the direct physiological outcomes of mitochondrial dysfunction, whether through reactive oxygen species (ROS) production or altered Ca2+ homeostasis. Introduction Atrial arrhythmias constitute a major public health probl...
Source: Frontiers in Physiology - Category: Physiology Source Type: research
From afar, the billions of stars in our galaxy look indistinguishable, just as the billions of star-shaped astrocytes in our brains appear the same as each other. But UCLA researchers have now revealed that astrocytes, a type of brain cell that supports and protects neurons, aren ’t all the same. While stars might be categorized by their size, age and heat, the supportive brain cells vary when it comes to shape, molecular machinery and functioning.The findings,published today in the journal  Neuron, should make it easier for researchers to study how astrocytes relate to disease, or to develop drugs that aim...
Source: UCLA Newsroom: Health Sciences - Category: Universities & Medical Training Source Type: news
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Source: Clinical Endocrinology - Category: Endocrinology Authors: Tags: Clinical Question Source Type: research
ConclusionThe use of ventilator‐induced CVPV could predict fluid responsiveness similar to SVV and PPV in post‐operative cardiac surgery patients.
Source: Acta Anaesthesiologica Scandinavica - Category: Anesthesiology Authors: Tags: Original Article Source Type: research
This study found that though it is often associated with coronary artery disease (CAD), it can also occur in those without significant CAD. It was not specifically associated with disease of right coronary artery disease. This cardioinhibitory response may be a manifestation of the Bezold-Jarisch reflex. Bezold-Jarisch reflex inhibits sympathetic activity (sympathetic withdrawal) and increases parasympathetic activity, resulting in bradycardia, which may be associated with vasodilatation, nausea and hypotension. Bezold-Jarisch has been described in the setting of inferior wall infarction and coronary angiography. Origin...
Source: Cardiophile MD - Category: Cardiology Authors: Tags: Cardiology MCQ Cardiology X-ray Featured Source Type: blogs
ATRIAL FIBRILLATION (AF) is the most common cardiac arrhythmia, with significant effects on patient quality of life and healthcare costs. Currently, more than 400,000 hospitalizations and 80,000 deaths annually are attributed to AF, with a substantial associated healthcare cost of $26 billion.1,2 Postoperative atrial fibrillation (POAF) is a unique entity seen in 16% to 30% of patients undergoing cardiac surgery and is associated with increased stroke, mortality, and hospital length of stay.3–5 The exact mechanism of POAF remains unknown, although it likely is multifactorial, caused by a combination of surgical stres...
Source: Journal of Cardiothoracic and Vascular Anesthesia - Category: Anesthesiology Authors: Tags: Editorial Source Type: research
This study aimed to test whether changes in continuous cardiac index (CCI), PPV, and stroke volume variation (SVV) after a mini-fluid challenge (100 ml of fluid during 1 min) could predict fluid responsiveness in these patients. Methods We prospectively studied 49 critically ill, deeply sedated, and mechanically ventilated patients (tidal volume
Source: British Journal of Anaesthesia - Category: Anesthesiology Authors: Tags: Critical Care Source Type: research
Conclusions: Vapor ablation is a potentially safe and efficient means of ablating a targeted region of the lung. We hypothesize that vapor may be useful in treating lesions of the lung in humans.Respiration
Source: Respiration - Category: Respiratory Medicine Source Type: research
Dr. Richard Schwab is a professor of medicine at the Hospital of the University of Pennsylvania. His groundbreaking research has used innovative imaging techniques to study the development of sleep apnea (when tissues in the mouth close during sleep, resulting in repeated airway obstructions and associated oxygen drops). In our conversation, he shared his insights on the most important facts in sleep apnea research: the high prevalence of the disorder, how obesity and alcohol can cause sleep apnea, the resulting cardiovascular problems, and the importance and ease of treatments. Here is a lightly edited transcript of our c...
Source: Science - The Huffington Post - Category: Science Source Type: news
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