Synthesis of 2'-aminouridine derivatives as an organocatalyst for Diels-Alder reaction †.
Synthesis of 2'-aminouridine derivatives as an organocatalyst for Diels-Alder reaction †.
Nucleosides Nucleotides Nucleic Acids. 2019 Jul 30;:1-19
Authors: Wakamatsu H, Itoh M, Natori Y, Yoshimura Y
Abstract
To develop a novel asymmetric organocatalyst based on a ribonucleoside skeleton, we designed and synthesized 2'-aminouridine derivatives. The synthesized 2'-aminouridines having bulky substituents at both base and sugar moieties could catalyze the Diels-Alder reaction between cinnamaldehyde and cyclopentadiene. However, the optical purities of the resulting products were unexpectedly low.
PMID: 31361181 [PubMed - as supplied by publisher]
Source: Nucleosides, Nucleotides and Nucleic Acids - Category: Biochemistry Tags: Nucleosides Nucleotides Nucleic Acids Source Type: research
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