Experimental Alzheimer's Drug Shows Promise, Study Finds

Title: Experimental Alzheimer's Drug Shows Promise, Study FindsCategory: Health NewsCreated: 3/11/2013 4:36:00 PMLast Editorial Review: 3/12/2013 12:00:00 AM
Source: MedicineNet Alzheimer - Category: Geriatrics Source Type: news

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Publication date: Available online 13 November 2019Source: Neurología (English Edition)Author(s): F.J. Ros Forteza
Source: Neurologia - Category: Neurology Source Type: research
Parkinson disease (PD) is the second most prevalent neurodegenerative disorder, next only to Alzheimer disease. As the average age of the United States and European populations increases, physicians caring for the elderly will be confronted with an increasing number of PD patients.
Source: Clinics in Geriatric Medicine - Category: Geriatrics Authors: Tags: Preface Source Type: research
This study was designed to test the hypothesis that nondependent alcohol drinking exacerbates the onset and magnitude of AD-like neural and behavioral pathology. We first evaluated the impact of voluntary 24-h, two-bottle choice home-cage alcohol drinking on the prefrontal cortex and amygdala neuroproteome in C57BL/6J mice and found a striking association between alcohol drinking and AD-like pathology. Bioinformatics identified the AD-associated proteins MAPT (Tau), amyloid beta precursor protein (APP), and presenilin-1 (PSEN-1) as the main modulators of alcohol-sensitive protein networks that included AD-related proteins ...
Source: International Review of Neurobiology - Category: Neuroscience Source Type: research
Publication date: 2019Source: International Review of Neurobiology, Volume 148Author(s): Terrence Deak, Lisa M. SavageAbstractIt is widely recognized that people worldwide are living longer than in previous decades, with formidable projections regarding the expansion of elderly age groups in the decades to come. Older individuals are also sustaining higher levels of alcohol consumption later in life, and binge drinking remains a prevalent pastime in a significant proportion of aged individuals. Older people are more sensitive to neurobehavioral effects of alcohol, and as individuals age, the cumulative impact of lifetime a...
Source: International Review of Neurobiology - Category: Neuroscience Source Type: research
Publication date: Available online 13 November 2019Source: Clinica Chimica ActaAuthor(s): Julia Oto, Álvaro Fernández-Pardo, Manuel Miralles, Emma Plana, Francisco España, Silvia Navarro, Pilar MedinaAbstractActivated protein C (APC) acts as an “on demand” anticoagulant, reducing thrombin formation. Reduced plasma levels of APC or protein C (PC) are associated with an increased risk of venous thromboembolism. APC also displays cytoprotective functions and its therapeutic use has been evaluated in severe sepsis and is under evaluation in several diseases with an important inflammatory compon...
Source: Clinica Chimica Acta - Category: Laboratory Medicine Source Type: research
o A. An Guettarda speciosa is known in traditional folk medicine for treating cough, cold, sore throat, fever, wounds, epilepsy, and headaches. To discover the scientific pharmacological potential of G. speciosa, we explore its anti-inflammatory, cytotoxicity, and inhibition of amyloid-beta (Aβ) aggregation effects. Cyclooxygenase assay of the G. speciosa CHCl3 (GSC) extract and G. speciosa MeOH (GSM) extract are more selective to COX-1 inhibition with a 50% inhibitory concentration (IC50) of 3.56 μg/mL for the GSC extract and 4.98 μg/mL for the GSM extract. Neuroblastoma SH-SY5Y inhibition and t...
Source: Molecules - Category: Chemistry Authors: Tags: Communication Source Type: research
Oligomannate, recently approved in China, is being met with some skepticism from researchers.
Source: The Scientist - Category: Science Tags: News & Opinion Source Type: news
CONCLUSIONS: Our results suggest that T1AM and TAAR1 are part of an endogenous system that can be modulated to prevent synaptic and behavioral deficits associated with Aβ-related toxicity. PMID: 31709926 [PubMed - as supplied by publisher]
Source: Thyroid : official journal of the American Thyroid Association - Category: Endocrinology Tags: Thyroid Source Type: research
(Natural News) Dementia is a collective term for diseases like Alzheimer’s that affect a person’s brain and his ability to think and remember. With over 50 million people having dementia worldwide and 10 million new cases being diagnosed annually, it is one of the fastest growing health conditions globally. Common signs of early-stage dementia are impaired cognitive...
Source: NaturalNews.com - Category: Consumer Health News Source Type: news
A study of 35 people with and without Alzheimer's disease found that hyperspectral imaging of the retina could aid early diagnosis of the disease.
Source: Health News from Medical News Today - Category: Consumer Health News Tags: Alzheimer's / Dementia Source Type: news
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