Mesothelioma Treatment in Toronto Moves from SMART to SMARTER

The Princess Margaret Cancer Center in Toronto has moved from SMART to SMARTER with the recent launch of its latest clinical trial for pleural mesothelioma patients. SMARTER is the acronym for Surgery for Mesothelioma After Radiation Therapy using Extensive pleural Resection, which also describes the latest clinical trial. The phase I clinical trial is an unconventional approach to treatment of mesothelioma: Find the maximum tolerated dosage of hypofractionated radiation to stimulate the immune system before aggressive surgery. It comes on the heels of the SMART protocol, which stands for Surgery for Mesothelioma After Radiation Therapy. It involved higher doses of radiation that required an more aggressive surgery. “The genesis for this latest trial is based on what we learned from the first version, the SMART version, and in terms of extending disease free outcomes, we were very pleased,” Dr. John Cho, radiation oncologist and principal trial investigator, told The Mesothelioma Center at Asbestos.com. “Now we’ve gone back to the drawing board, looking for similar results but with a much less aggressive procedure.” Impressive Earlier Survival Times The research team in Toronto reported a three-year survival rate of 66% among patients with the epithelial mesothelioma subtype and no lymph node involvement while using the SMART approach. They also estimated a median overall survival of 51 months and disease-free survival at 47 months. The high-dose radiation administ...
Source: Asbestos and Mesothelioma News - Category: Environmental Health Authors: Source Type: news