Brain abnormalities on CT, MRI indicate severe Zika

Structural abnormalities visible on the brain MRI and CT scans of infants with...Read more on AuntMinnie.comRelated Reading: Can prenatal ultrasound predict Zika infection outcomes? Zika's effects hard to detect on ultrasound, MRI MRI advances detection of Zika-related brain abnormalities Studies at RSNA offer new insights into Zika's spread Zika's rapid spread on MRI scans shocks researchers
Source: AuntMinnie.com Headlines - Category: Radiology Source Type: news

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by Shengzhang Dong, Seokyoung Kang, George Dimopoulos Zika virus (ZIKV), an emerging arbovirus belonging to the genus Flavivirus, is transmitted byAedes mosquitoes. ZIKV infection can cause microcephaly of newborn babies and Guillain –Barré syndrome in adults. Because no licensed vaccine or specific antiviral treatment is available for ZIKV infection, the most commonly used approach to control the spread of ZIKV is suppression of the mosquito vector population. A novel proposed strategy to block arthropod virus (arbovirus) tr ansmission is based on the chemical inhibition of virus infection in mosquitoes. How...
Source: PLoS Neglected Tropical Diseases - Category: Tropical Medicine Authors: Source Type: research
Publication date: Available online 16 August 2019Source: MicronAuthor(s): Lilian Mirian Oliveira de Morais, Eduardo Inocente Jussiani, João Antonio Cyrino Zequi, Paulo José dos Reis, Avacir Casanova AndrelloAbstractAedes aegypti and Aedes albopictus are vectors of several arboviruses responsible for causing dengue, chikungunya, Zika, and yellow fever viruses and microcephaly, resulting in a public health problem in several countries worldwide. Even in this scenario, studies on the morphology of mosquito eggs are still lacking. In this paper, X-ray microtomography was used to study mosquito egg morphology. Sev...
Source: Micron - Category: Biology Source Type: research
Severe birth defects caused by the Zika virus may be related to the antibodies infected mothers produce to fight the disease, a study by YSPH researchers shows.
Source: Yale Science and Health News - Category: Universities & Medical Training Source Type: news
CONCLUSIONS: The co-circulation of those viruses in the same area represents a risk for the development of severe infections if they spread throughout the country. Successive flavivirus infections may have an impact on disease pathogenesis, as well as on the development of safe vaccine strategies. PMID: 31411310 [PubMed - in process]
Source: Memorias do Instituto Oswaldo Cruz - Category: Infectious Diseases Authors: Tags: Mem Inst Oswaldo Cruz Source Type: research
Contributors : Lauretta A Lacko ; Lei Tan ; Shuibing ChenSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusTo determine the effect of Zika virus infection on pre-implantation embryonic development, we performed single blastocyst RNA-Seq on MOCK and ZIKV infected embryos. ZIKV infection results in an increased risk of spontaneous abortion and poor intrauterine growth although the mechanisms underlying fetal loss remain undetermined. Little is known about the impact of ZIKV infection during the earliest stages of pregnancy, or pre- and peri-implantation, because most current studies of Z...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
Zika virus (ZIKV) infection during pregnancy is associated with microcephaly, a congenital malformation resulting from neuroinflammation and direct effects of virus replication on the developing central nervous system (CNS). However, the exact changes in the affected CNS remain unknown. Here, we show by transcriptome analysis (at 48 hours post-infection) and multiplex immune profiling that human induced-neuroprogenitor stem cells (hiNPCs) respond to ZIKV infection with a strong induction of type I interferons (IFNs) and several type I IFNs stimulated genes (ISGs), notably cytokines and the pro-apoptotic chemokines CXCL9 an...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
This study defines grp94 as a crucial host factor for flavivirus replication and identified CDDO-me as a potent small molecule inhibitor of flavivirus infection. Inhibition of grp94 may contribute to the antiviral activity of CDDO-me. Further investigation of grp94 inhibitors may lead to a new class of broad-spectrum anti-flaviviral medications.
Source: Antiviral Therapy - Category: Virology Source Type: research
Conclusions: The results showed that the network topology exhibits the features of a scale-free network instead of a random network. Focal hubs are highlighted and the critical period is found. Outcomes are important for the researchers, health officials, and policy makers who deal with arbovirus epidemic diseases. Zika virus and Chikungunya virus can also be modelled and analyzed in this manner. PMID: 31406610 [PubMed]
Source: Healthcare Informatics Research - Category: Information Technology Tags: Healthc Inform Res Source Type: research
Source: World Health Organization (WHO). Published: 8/14/2019. This 25-minute video features live responses from an expert to questions about dengue, which is transmitted through Aedes aegypti and Aedes Albopictus mosquitoes, also known as Asian tiger mosquitoes. These are the same mosquitoes that transmit chikungunya, yellow fever, and Zika. Topics include identifying the warning signs and symptoms of severe dengue, and complications caused by dengue. (Video or Multimedia)
Source: Disaster Lit: Resource Guide for Disaster Medicine and Public Health - Category: International Medicine & Public Health Source Type: news
Zika virus (ZIKV) is a newly emerging flavivirus that broadly exhibits in various bodily tissues and fluids, especially in the brain, and ZIKV infection often causes microcephaly. Previous studies have been reported that ZIKV can infect renal cells and can be detected in the urine samples of infected individuals. However, whether ZIKV infection causes renal diseases and its pathogenic mechanisms remains unknown. Here, we identified that ZIKV infection resulted in acute kidney injury (AKI) in both newborn and adult mouse models by increasing the levels of AKI-related biomarkers [e.g., serum creatinine (Scr), kidney injury m...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
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