Risk modelling the mortality impact of antimicrobial resistance in secondary pneumococcal pneumonia infections during the 2009 influenza pandemic

Antimicrobial resistance (AMR) is an important factor for consideration in pandemic preparedness. Any reduction in treatability poses a potential risk to national and international security and economic stability when applied to pandemic-related pathogens (McArthur and Tsang, 2017). Increasing AMR among pathogens responsible for the development of community-acquired pneumonia (CAP) (e.g., Streptococcus pneumoniae and Haemophilus influenzae) (Adam, 2002) is especially concerning given their propensity to cause bacterial infections secondary to viral influenza.
Source: International Journal of Infectious Diseases - Category: Infectious Diseases Authors: Source Type: research

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Publication date: Available online 11 September 2019Source: Journal of Hospital InfectionAuthor(s): E. Skelly, M. Skally, M. Foley, L. Gaughan, F. Duffy, K. Burns, H. Humphreys, F. Fitzpatrick
Source: Journal of Hospital Infection - Category: Infectious Diseases Source Type: research
ConclusionsCompared to linezolid treatment, daptomycin treatment showed comparable clinical and microbiological outcomes but a lower incidence of thrombocytopenia. Because of the dose-dependent effect observed, high-dose daptomycin should be considered for patients with VRE bacteraemia.
Source: Journal of Global Antimicrobial Resistance - Category: Infectious Diseases Source Type: research
ConclusionsSOPs may provide a good starting point for increasing adult immunization coverage rates. Using additional interventions, quality-based metrics, or incentives could lead to sustained adult immunization prioritization.
Source: American Journal of Infection Control - Category: Infectious Diseases Source Type: research
Jared Dunnmon Luke Oakden-Rayner By LUKE OAKDEN-RAYNER MD, JARED DUNNMON, PhD Medical AI testing is unsafe, and that isn’t likely to change anytime soon. No regulator is seriously considering implementing “pharmaceutical style” clinical trials for AI prior to marketing approval, and evidence strongly suggests that pre-clinical testing of medical AI systems is not enough to ensure that they are safe to use.  As discussed in a previous post, factors ranging from the laboratory effect to automation bias can contribute to substantial disconnects between pre-clinical performance of AI sys...
Source: The Health Care Blog - Category: Consumer Health News Authors: Tags: Artificial Intelligence Data Health Tech Health Technology AI Jared Dunnmon Luke Oakden-Rayner machine learning Source Type: blogs
Conditions:   Influenza;   Critical Illness Intervention:   Diagnostic Test: influenza screening Sponsor:   University of Bordeaux Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
"Japan Diet" and Health-The Present and Future. J Nutr Sci Vitaminol (Tokyo). 2019;65(Supplement):S29-S33 Authors: Teramoto T Abstract Japan achieved remarkable economic development after World War II, which has led remarkable changes in risk factors of atherosclerotic diseases and led to epidemiological transition in Japan. Nowadays, obesity is pandemic around world, which is same case in Japan. BMI of Japanese population, especially young adult men increased gradually since the 1960s associated with increase in intake of fat as well as decrease in intake of rice, which has been revealed by ...
Source: Journal of Nutritional Science and Vitaminology - Category: Nutrition Tags: J Nutr Sci Vitaminol (Tokyo) Source Type: research
Authors: Yu H, Wang Y, Wang X, Guo J, Wang H, Zhang H, Du F Abstract Bacterial resistance to antimicrobial agents, including multidrug resistance, is an increasing problem in the treatment of infectious diseases. The development of resistance-modifying agents represents a potential strategy to alleviate the spread of bacterial resistance to antibiotics. A checkerboard microdilution assay was used to determine the synergy of jatrorrhizine and the antibiotic, norfloxacin (NFX). A bacterial ethidium bromide efflux assay, reverse transcription semi-quantitative polymerase chain reaction analysis and molecular docking s...
Source: Experimental and Therapeutic Medicine - Category: General Medicine Tags: Exp Ther Med Source Type: research
CONCLUSION: A variety of approaches can be effective. Focusing training sessions for medical practice teams on certain diseases may be of greater benefit than vacci- nation-centered training sessions. Reminder systems for doctors should be more reliably implemented. Simple strategies are perhaps the most suitable ones in the heterogeneous population of chronically ill persons. The limitations of this system- atic review include the heterogeneity of the studies that we examined and the small number of studies in each category. PMID: 31617479 [PubMed - in process]
Source: Deutsches Arzteblatt International - Category: General Medicine Tags: Dtsch Arztebl Int Source Type: research
New J. Chem., 2019, Accepted Manuscript DOI: 10.1039/C9NJ02460C, PaperSamuel Trevi ño, Enrique Gonzalez-Vergara Diabetes mellitus is a pandemic expected to spread from 422 million patients in 2014 to 592 million patients in 2035. Type 1 diabetes mellitus (T1D) is characterized by both autoimmune... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - New J. Chem. latest articles - Category: Chemistry Authors: Source Type: research
Abstract Humoral immunological defects are frequent and important causes of hypogammaglobulinemia, leading to recurrent infections, autoimmunity, allergies, and neoplasias. Usually, its onset occurs in childhood or during the second and third decades of life; however, the diagnosis is made, on average, 6 to 7 years afterwards. As a consequence, antibody defects can lead to sequelae. Here we describe the clinical-laboratory characteristics, treatment, and prognoses of patients with hypogammaglobulinemia. An observational, cross-sectional, and retrospective study of patients attending the recently established outpat...
Source: Braz J Med Biol Res - Category: Research Authors: Tags: Braz J Med Biol Res Source Type: research
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