The use of glycated haemoglobin (HbA1C) in determining glycemic control (and relevance of BMI) in diabetic patients in ABUTH Zaria, Nigeria

This study was carried out to specifically investigate the local HbA1C normal level and determine extent of (if any) variation from the WHO (World Health Organization) recommended threshold for the onset of diabetes and prediabetes using blood glucose as a benchmark. In addition, we also looked to see what role BMI plays among subjects used for the study.152 subjects were used for the study: 101 diabetic subjects and 51 non-diabetic control subjects. 5 mL of blood sample was collected from each of the subjects after about 8–10 h of overnight fasting. 3–4 mL of the sample was centrifuged and the serum analysed for glucose. The remaining 1–2 ml was transferred into EDTA bottles and analysed immediately for glycated haemoglobin (HbA1C). The BMI (kg/m2) was calculated by dividing the weight in kilograms (kg) by the square of the height in metres (m2).For the BMI, no significant difference was observed between the diabetic subjects (mean = 25.75 kg/m2) and the non-diabetic control subjects (mean = 25.09 kg/m2). Thirty-seven (37) of the diabetic subjects and twenty-three (23) of the non-diabetic subjects had HbA1C levels (mean = 6.96% and 6.29% respectively) that would imply either prediabetes or diabetes but were actually normal going by their blood glucose levels. A new chart for the determination of normal, prediabetic and diabetic HbA1C level was realized, drawn up and recommended for consideration in the management of diabetic patients along with ...
Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews - Category: Endocrinology Source Type: research