Re: “AA IDO1 Variant Genotype (G2431A, rs3739319) Is Associated with Severe Dengue (SD) Risk Development in a DEN-3 Brazilian Cohort” by Azevedo et al. (Viral Immunol 2019;14 DOI: 10.1089/vim.2018.0149)
Viral Immunology, Ahead of Print.
ConclusionsThis study reports the first DENV detection in saliva of BALB/c immunocompetent mice experimentally infected with nonneuroadapted DENV-4.
The use of saliva as an alternative detection fluid for viral diseases has been proved to be very efficient in the molecular diagnosis of viruses and in the epidemiologic study of viral diseases, a public health problems. Besides allowing the early diagnosis, viral detection in saliva is performed in a noninvasive way, which facilitates the whole process.
Authors: Devarasu N, Sudha GF Abstract A noninvasive investigation to ascertain the platelet (PLT) count was conducted on 44 hospitalized dengue hemorrhagic fever (DHF) subjects, male and female aged between 3 and 14 years using bioelectrical phase angle (BPhA). Among the 44 subjects, 30 subjects were confirmed to be non-structural protein-1 (NS1) positive at the time of admission, whose blood investigations such as hematocrit (HCT) level, PLT count, aspartate aminotransferase (AST) level and alanine aminotransferase (ALT) level were performed for the classification of risk as low-risk (LR) and high-risk (HR) DHF. ...
ela Korovou Climate change is known to affect Pacific Island nations in a variety of ways. One of them is by increasing the vulnerability of human health induced by various climate change impacts, which pose an additional burden to the already distressed health systems in the region. This paper explores the associations between climate change and human health on the one hand, and outlines some of the health care challenges posed by a changing climate on the other. In particular, it describes the links between climate variations and the emergence of climate-sensitive infectious diseases, such as the mosquito-borne disea...
Publication date: 14–20 December 2019Source: The Lancet, Volume 394, Issue 10215Author(s): Annelies Wilder-Smith, Stefan Flasche, Peter G Smith
Publication date: 14–20 December 2019Source: The Lancet, Volume 394, Issue 10215Author(s): Basu Dev Pandey, Anthony Costello
Publication date: 14–20 December 2019Source: The Lancet, Volume 394, Issue 10215Author(s): Mohammed A Mamun, Jannatul Mawa Misti, Mark D Griffiths, David Gozal
Publication date: 14–20 December 2019Source: The Lancet, Volume 394, Issue 10215Author(s): Thais Helena dos Santos, Jose L San Martin, Luis G Castellanos, Marcos A Espinal
This study aimed to compare the replicative fitness of the four dengue virus serotypes and understand the association between the serotypes, their in vitro infection ability, and their replication in target cells. We used three isolates of each DENV serotype to infect Huh-7 cells at an MOI of 0.5. The percentage of infected cells was evaluated by flow cytometry, cell viability was evaluated by MTT assay, and the pathogenicity index was calculated as a ratio of both parameters. The replicative fitness was measured by the number of viral genome copies produced using quantitative PCR and the production of infectious viral pro...