Morphologic and genomic characterization of urothelial to sarcomatoid transition in muscle-invasive bladder cancer.

CONCLUSIONS: Conventional urothelial and adjacent sarcomatoid morphologies of MIBC arise from the same common ancestor and share a basal-like phenotype. However, divergence between the morphologies at the genome, transcriptome, and proteome level suggests differential sensitivity to therapy.
PMID: 31358384 [PubMed - as supplied by publisher]

Source: Urologic Oncology - July 25, 2019 Category: Urology & Nephrology Authors: Genitsch V, Kollár A, Vandekerkhove G, Blarer J, Furrer M, Annala M, Herberts C, Pycha A, de Jong JJ, Liu Y, Krentel F, Davicioni E, Gibb EA, Kruithof-de Julio M, Wyatt AW, Seiler R Tags: Urol Oncol Source Type: research