The Magnitude of IFN- γ Responses Is Fine-Tuned by DNA Architecture and the Non-coding Transcript of Ifng-as1

Petermann et  al. report that the long non-coding RNA locus Ifng-as1 is an important regulator of Ifng. It does so through its role as a modifier of DNA structure, but also through transcription of the lncRNA itself, which is involved in dynamic and cell state-specific regulation of IFN-γ-mediated host defense .

Source: Molecular Cell - July 30, 2019 Category: Cytology Authors: Franziska Petermann, Aleksandra P ękowska, Catrina A. Johnson, Dragana Jankovic, Han-Yu Shih, Kan Jiang, William H. Hudson, Stephen R. Brooks, Hong-Wei Sun, Alejandro V. Villarino, Chen Yao, Kentner Singleton, Rama S. Akondy, Yuka Kanno, Alan Sher, Rafae Tags: Article Source Type: research