Early Scanning of Nascent Polypeptides inside the Ribosomal Tunnel by NAC

NAC is an essential ribosome-associated protein biogenesis factor. Gamerdinger et  al. demonstrate that NAC deeply inserts into the ribosomal tunnel to sense nascent polypeptide chains directly upon birth. The early scanning of nascent polypeptides inside the ribosomal tunnel is crucial for the correct sorting of proteins in the cell.

Source: Molecular Cell - July 30, 2019 Category: Cytology Authors: Martin Gamerdinger, Kan Kobayashi, Annalena Wallisch, Stefan G. Kreft, Carolin Sailer, Renate Schl ömer, Nadine Sachs, Ahmad Jomaa, Florian Stengel, Nenad Ban, Elke Deuerling Tags: Article Source Type: research