Epitope Mapping of Anti-Diacylglycerol Kinase Zeta Monoclonal Antibody DzMab-1 for Immunohistochemical Analyses.

In this study, we characterized the binding epitope of DzMab-1 using Western blotting, and found that Met1 and Pro3 residues of hDGKζ are important for facilitating DzMab-1 binding to hDGKζ. Furthermore, DzMab-1 was shown to be useful for immunohistochemical analyses for formalin-fixed paraffin-embedded HeLa cells. These findings could be applied for the production of more functional anti-hDGKζ mAbs. PMID: 31355694 [PubMed - as supplied by publisher]
Source: Monoclonal Antibodies in Immunodiagnosis and Immunotherapy - Category: Microbiology Tags: Monoclon Antib Immunodiagn Immunother Source Type: research

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Publication date: Available online 17 November 2019Source: European Polymer JournalAuthor(s): Samson O. Aisida, Paul A. Akpa, Ishaq Ahmad, Ting-kai Zhao, M. Maaza, Fabian I. EzemaAbstractCancer cells are typified by proliferating mass of cells that grow faster than other smaller cell tissues within the body. Efforts to combat this effect through chemotherapy, radiotherapy, immunotherapy and surgery are still challenging. Magnetic Iron oxide nanoparticles (FeO-NPs) encapsulated with biopolymers as a local drug delivery system with the control via an external magnetic field has been widely used as a drug delivery system in c...
Source: European Polymer Journal - Category: Chemistry Source Type: research
Authors: Zhu Y, Deng J, Nan ML, Zhang J, Okekunle A, Li JY, Yu XQ, Wang PH Abstract Pattern recognition receptors (PRRs) are sensors of exogenous and endogenous "danger" signals from pathogen-associated molecular patterns (PAMPs), and damage associated molecular patterns (DAMPs), while autophagy can respond to these signals to control homeostasis. Almost all PRRs can induce autophagy directly or indirectly. Toll-like receptors (TLRs), Nod-like receptors (NLRs), retinoic acid-inducible gene-I-like receptors (RLRs), and cyclic guanosine monophosphate-adenosine monophosphate synthase (cGAS)-stimulator of int...
Source: Advances in Experimental Medicine and Biology - Category: Research Tags: Adv Exp Med Biol Source Type: research
Concerns over staffing needs and the risk for anaphylaxis with new oral immunotherapies have physicians questioning the next steps.Medscape Medical News
Source: Medscape Medical News Headlines - Category: Consumer Health News Tags: Allergy & Clinical Immunology News Source Type: news
Publication date: Available online 18 November 2019Source: The Journal of Allergy and Clinical Immunology: In PracticeAuthor(s): Tomas Moraly, Diane Pelletier de Chambure, Stephane Verdun, Christian Preda, Maxime Seynave, Anne-Christine Vilain, Cecile Chenivesse, Christine Delebarre-SauvageAbstractBackgroundOral immunotherapy (OIT) protects patients with IgE-mediated food allergies from food-induced allergic reactions due to accidental exposure and may improve their quality of life. This approach has never been evaluated for hazelnut, a major cause of food allergy in Europe.ObjectiveWe sought to determine the proportion of...
Source: The Journal of Allergy and Clinical Immunology: In Practice - Category: Allergy & Immunology Source Type: research
The worst possible outcome when developing a clinical therapy is not an early failure. It is a late failure, in the final and most expensive phase III clinical trial, in which the therapy interacts with a sizable patient population, and after a great deal of time and funding have been devoted to the program. This result is far more likely for therapies based on mechanisms that have smaller rather than larger effect sizes, and where that smaller effect size varies from individual to individual for reasons that are not well understood - something that describes all too much of the past few decades of efforts to treat age-rel...
Source: Fight Aging! - Category: Research Authors: Tags: Medicine, Biotech, Research Source Type: blogs
Condition:   Advanced Malignant Solid Tumor Intervention:   Other: Plasmodium immunotherapy Sponsor:   CAS Lamvac Biotech Co., Ltd. Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Leukemia, Published online: 18 November 2019; doi:10.1038/s41375-019-0639-xRIG-I-based immunotherapy enhances survival in preclinical AML models and sensitizes AML cells to checkpoint blockade
Source: Leukemia - Category: Hematology Authors: Source Type: research
Canonical WNT/β-catenin signaling is involved in most of the mechanisms that lead to the formation and development of cancer cells. It plays a central role in three cyclic processes, which are the cell division cycle, the immune cycle, and circadian rhythms. When the canonical WNT pathway is upregulated as in cancers, the increase in β-catenin in the nucleus leads to activation of the expression of numerous genes, in particular CYCLIN D1 and cMYC, where the former influences the G1 phase of the cell division cycle, and the latter, the S phase. Every stage of the immune cycle is disrupted by the canonical WNT sign...
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
Nature, Published online: 18 November 2019; doi:10.1038/d41586-019-03495-3Immunotherapy approaches seek to boost immune responses against cancer. A single antibody engineered to recognize three targets shows promise, when tested in animals, in improving the ability of T cells to target cancer.
Source: Nature AOP - Category: Research Authors: Source Type: research
AbstractPurpose of ReviewT cell lymphoproliferative disorders represent a diverse group of hematologic malignancies with poor prognosis underscoring the need for novel therapeutic approaches. Disruption of the JAK/STAT signaling pathway has been described in this group of blood cancers and may represent an approach for targeted therapy. Here, we summarize the current data describing the disruptions of JAK/STAT signaling in T cell malignancies and focus on the existing evidence for exploitation of this pathway with targeted therapies.Recent FindingsTo date, preclinical studies have demonstrated the efficacy of JAK/STAT inhi...
Source: Current Hematologic Malignancy Reports - Category: Hematology Source Type: research
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