Endoscopic full-thickness resection (EFTR) in the lower gastrointestinal tract

ConclusionsEFTR yields excellent resection rates for benign recurrent adenomas with non-lifting sign, advanced histopathological findings or submucosal lesions when the procedure is performed in experienced hands and for the correct indication. Thus, surgery can be avoided in many cases. For all lesions the risk of R1 resection goes up with the size of the lesion and careful patient selection is mandatory.
Source: Techniques in Coloproctology - Category: Surgery Source Type: research

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Programmed cell death 4 (PDCD4) is a tumor suppressor gene implicated in many cellular functions, including transcription, translation, apoptosis, and the modulation of different signal transduction pathways. The downstream mechanisms of PDCD4 have been well-discussed, but its upstream regulators have not been systematically summarized. Noncoding RNAs (ncRNAs) are gene transcripts with no protein-coding potential but play a pivotal role in the regulation of the pathogenesis of solid tumors, cardiac injury, and inflamed tissue. In recent studies, many ncRNAs, especially microRNAs (miRNAs) and long noncoding RNAs (lncRNAs), ...
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
In conclusion, xantoxyletin primarily show potential anticancer activity. The root bark of C. harmandiana is a good source of bioactive compounds or the lead for the development of new pharmaceutical agent.
Source: Molecules - Category: Chemistry Authors: Tags: Article Source Type: research
ConclusionsPET/CT was useful for early detection of EPCs. The use of PET/CT for the early detection and treatment of EPCs with no symptoms can improve treatment outcomes.
Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology - Category: ENT & OMF Source Type: research
Epithelial homeostasis and regeneration require a pool of quiescent cells. How the quiescent cells are established and maintained is poorly understood. Here we report that Trpv6, a cation channel responsible for epithelial Ca2+ absorption, functions as a key regulator of cellular quiescence. Genetic deletion and pharmacological blockade of Trpv6 promoted zebrafish epithelial cells to exit from quiescence and re-enter the cell cycle. Reintroducing Trpv6, but not its channel dead mutant, restored the quiescent state. Ca2+imaging showed that Trpv6 is constitutively open in vivo. Mechanistically, Trpv6-mediated Ca2+ influx mai...
Source: eLife - Category: Biomedical Science Tags: Developmental Biology Source Type: research
dde The adenoma-to-carcinoma progression in colon cancer is driven by a sequential accumulation of genetic alterations at specific tumor suppressors and oncogenes. In contrast, the multistage route from the primary site to metastasis formation is underlined by phenotypic plasticity, i.e., the capacity of disseminated tumor cells to undergo transiently and reversible transformations in order to adapt to the ever-changing environmental contexts. Notwithstanding the considerable body of evidence in support of the role played by epithelial-to-mesenchymal transition (EMT)/mesenchymal-to-epithelial transition (MET) in metast...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Review Source Type: research
CONCLUSION: Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy for isolated low-volume colorectal peritoneal metastases are not safe and effective, with low morbidity. It offers selected patients a highly favorable overall and relapse-free survival. See Video Abstract at http://links.lww.com/DCR/B2. EVOLUCIÓN DE LA CIRUGÍA CITORREDUCTIVA Y QUIMIOTERAPIA INTRAPERITONEAL HIPERTÉRMICA (HIPEC) PARA METÁSTASIS PERITONEALES COLORRECTALES: EXPERIENCIA INSTITUCIONAL DE 8 AÑOS ANTECEDENTES: El cáncer colorrectal es la segunda causa de mortalidad relacionada con el c&a...
Source: Diseases of the Colon and Rectum - Category: Gastroenterology Tags: Original contributions: Colorectal Cancer Source Type: research
Publication date: 1 December 2019Source: Materials Letters, Volume 256Author(s): Manal A. Awad, Nada E. Eisa, Promy. Virk, Awatif A. Hendi, Khalid M.O.O. Ortashi, AbdAlla S.A. Mahgoub, Mai A. Elobeid, Fahd Z. EissaAbstractSynthesis of nanostructures using green chemistry has been popular owing to the exciting properties and innovative applications of these nanostructures. Novel, cost-effective, and eco-friendly gold nanoparticles (Au NPs) were synthesized using a mix of Olea europaea (OE) fruit extract and Acacia nilotica (AN) husk extract. The synthesized Au NPs were characterized by UV–visible spectroscopy, and the...
Source: Materials Letters - Category: Materials Science Source Type: research
A 63-year-old woman with neuroendocrine carcinoma of the colon was referred to our department for staging with 99mTc-octreotide scan. Two focal, highly intense, superficial lesions were detected in patient's scalp and paralumbar region, medial to the right kidney. Pathology correlation was recommended, revealing them both to be benign trichilemmal cysts. This unexpected finding strengthens the hypothesis of Merkel cell carcinoma and trichilemmal cysts originating from pluripotent stem cells of adnexal epithelium, making a neuroendocrine differentiation for the latter plausible.
Source: Clinical Nuclear Medicine - Category: Nuclear Medicine Tags: Interesting Images Source Type: research
Authors: Siekmann W, Tina E, Von Sydow AK, Gupta A Abstract Regional anesthesia may prolong survival following surgery for different types of cancers. The mechanisms behind this are unclear but direct effects on cancer cells by local anesthetics (LA) have been suggested. The aim of this study was to investigate if lidocaine or ropivacaine have a dose-dependent effect on the cell viability and proliferation of a primary and a secondary colon carcinoma cell line in vitro. The colon cancer cell lines SW480 derived from primary tumor and SW620 from a metastatic site in the same patient were exposed to increasing concen...
Source: Oncology Letters - Category: Cancer & Oncology Tags: Oncol Lett Source Type: research
Publication date: Available online 9 September 2019Source: Journal of Organometallic ChemistryAuthor(s): Sepideh Samiee, Ahmadreza Shiralinia, Elham Hoveizi, Robert W. GableAbstractIn the present investigation, the reactivity of an oxime-derived palladacycle [Pd{C,N–C6H4{C(Me) = NOH}-2}(μ-Cl)]2 toward various unsymmetrical phosphorus ylides has been studied. When the ylide was added to a solution of oxime complex in dichloromethane (2:1 ratio), the new oxime palladacycles of the types [Pd{C,N–C6H4{C(Me) = NOH}-2}(Ph2PCH2PPh2C(H)C(O)C6H4X)]ClO4 (X = Cl (1), Br (2), NO2(3) or OCH3 (4)) were formed ...
Source: Journal of Organometallic Chemistry - Category: Chemistry Source Type: research
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