Ameliorative Effect of Berberine on Neonatally Induced Type 2 Diabetic Neuropathy via Modulation of BDNF, IGF-1, PPAR- γ, and AMPK Expressions.
In conclusion, berberine exerts its neuroprotective effect against n-STZ-induced diabetic peripheral neuropathy via modulation of pro-inflammatory cytokines (TNF α, IL-1β, and IL-6), oxido-nitrosative stress, BDNF, IGF-1, PPAR-γ, and AMPK expression to ameliorate impaired allodynia, hyperalgesia, and nerve conduction velocity during T2DM.
PMID: 31360147 [PubMed]
Source: Dose Response - Category: Drugs & Pharmacology Authors: Zhou G, Yan M, Guo G, Tong N Tags: Dose Response Source Type: research
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