Prevalence of prediabetes and diabetes in children and adolescents with biopsy-proven non-alcoholic fatty liver disease

With the growing prevalence of childhood obesity, pediatric non-alcoholic fatty liver disease (NAFLD) has emerged as the most common chronic liver disease in children and adolescents in Western countries.1 –3 NAFLD is a spectrum of progressive liver disease that encompasses simple steatosis, non-alcoholic steatohepatitis (NASH), advanced fibrosis and, ultimately, cirrhosis.3,4 Compelling evidence indicates that NAFLD also has serious health consequences outside of the liver and is strongly associate d with an increased risk of cardiovascular disease and abnormal glucose tolerance (prediabetes and type 2 diabetes).

Source: Journal of Hepatology - July 3, 2019 Category: Gastroenterology Authors: Valerio Nobili, Alessandro Mantovani, Stefano Cianfarani, Anna Alisi, Antonella Mosca, Maria Rita Sartorelli, Claudio Maffeis, Rohit Loomba, Christopher D. Byrne, Giovanni Targher Source Type: research