EP News: Basic and Translational

In the current study, Lussier et  al (Sci Rep 2019;9:9113, PMID 31235733) tested the functional significance of the stoichiometries of the 4 hyperpolarization-activated cyclic nucleotide–gated (HCN) channel isoforms and their auxiliary subunit KCNE2 using single-molecule subunit counting. The number of KCNE2 subunits in complex with the pore-forming subunits of human HCN channels differs with each HCN isoform and is dynamic with respect to concentration. Moreover, these interactions can be altered by KCNE2 gene variants.
Source: Heart Rhythm - Category: Cardiology Authors: Tags: EP News Source Type: research
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