Anesthetic Management of a Patient With Type 1 Long QT Syndrome Using Combined Epidural-Spinal Anesthesia for Caesarean Section: Perioperative Approach Based on Ion Channel Function

CONGENITAL LONG QT syndrome (LQTS) is the most common of genetic arrhythmia syndromes associated with lethal ventricular arrhythmias and sudden cardiac death in an otherwise healthy young population.1 Hundreds of mutations in genes linked to LQTS have been identified. Although at least 17 genotypes of congenital LQTS have been reported to date, types 1, 2, and 3 LQTS (LQT1, LQT2, and LQT3, respectively) amount to approximately 90% of all genotype-confirmed cases.2,3 LQT1 is caused by loss-of-function mutations in KCNQ1 gene encoding α-subunit of cardiac slowly activating delayed rectifier K+ channel (IKs channel).

Source: Journal of Cardiothoracic and Vascular Anesthesia - July 29, 2019 Category: Anesthesiology Authors: Eisuke Hashimoto, Akiko Kojima, Hirotoshi Kitagawa, Hiroshi Matsuura Tags: Case Report Source Type: research