Lichen Planus in Ear Not Uncommon

MIAMI BEACH (MedPage Today) -- The autoimmune disease lichen planus may affect the ear more commonly than previously thought, researchers reported here.
Source: MedPage Today Dermatology - Category: Dermatology Source Type: news

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This study included 89 paraffin-embedded blocks contain OLP (44 cases), CLP (45 cases) and NOM from the archive of Mashhad University of Medical Sciences, Mashhad, Iran. The expression of RORγt and IL-17 was evaluated by Real-time RT-PCR method. The result was compared to Leukocyte counts and the other hematological parameters of studied patients.RESULTS: The results of our study showed IL-17 and RORγt expression in OLP lesions were significantly higher than CLP and NOM groups (P = 0.001). Although we found high expression of RORγt and IL-17 in erosive OLP in compared to classic OLP lesion, but this incre...
Source: Cytokine - Category: Molecular Biology Authors: Source Type: research
Discussion Lichen sclerosus et atrophicus (LSA) is a chronic inflammatory disease with a strong autoimmune association. It can occur with other autoimmune diseases. Its specific cause is unknown. It affects females and males of all ages, but especially females 40-60 years. In the pediatric population it affects prepubertal females most often. Treatment includes steroid medications or anti-inflammatory medications. Other treatments may be offered including phototherapy, and much less commonly systemic steroids or immunosuppressive therapy. Circumcision may also be an option for some males. Childhood LSA generally improves b...
Source: - Category: Pediatrics Authors: Tags: Uncategorized Source Type: news
Actas Dermosifiliogr. 2021 Aug 2. doi: 10.1016/ Online ahead of print.ABSTRACTHydroxychloroquine is an antimalarial drug with immunomodulatory, anti-inflammatory, antibacterial, and antiviral properties. It has a good safety profile, can be used in children and in pregnant and breastfeeding women, and does not suppress the immune system. Regular screening for retinopathy, one of the drug's most feared adverse effects, is necessary. Hydroxychloroquine is a widely used, essential drug in dermatology. Clinical response rates are good in lupus erythematous, where it is a first-line therapy, as well in numerous...
Source: Actas Dermo-Sifiliograficas - Category: Dermatology Authors: Source Type: research
ConclusionsThe dermoscopic features observed in cGvHD affecting lip vermillion warrant differentiation with inflammatory (lichen planus), autoimmune (lichen sclerosus, discoid lupus erythematosus), precancerous (actinic keratosis, leukoplakia), and neoplastic diseases (squamous cell carcinoma), among others. Dermoscopy of lip vermillion might be an additional tool to visualize diagnostic mucoscopic features of cGvHD (lichen planus-like, lichen sclerosus-like lesions).
Source: Dermatology and Therapy - Category: Dermatology Source Type: research
DISCUSSION: The study design is based on experience from studies on apremilast in other inflammatory skin diseases using equivalent apremilast doses for approved indications. The trial may provide evidence for the use of apremilast in women with this burdensome genital dermatosis.TRIAL REGISTRATION: NCT0365666 . Registered on 4 September 2018.PMID:34284808 | PMC:PMC8290211 | DOI:10.1186/s13063-021-05428-w
Source: Pain Physician - Category: Anesthesiology Authors: Source Type: research
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