The bidirectional relationship between host physiology and microbiota and health benefits of probiotics: A review

Conclusions: Microbial ecosystem has a symbiotic relationship with host. The alteration in the host physiology and shift in the microbial composition in the hosts can positively or negatively impact each other. The clear and thorough comprehension of the complexity of microbiota–host crosstalk is significant for the development of probiotic intervention. Probiotic may confer various benefits ranging from traditional immune support, gastrointestinal heath even to disease control as sepsis prevention. Probiotic may function in the host mainly through competing with deleterious bacteria, beneficial metabolites and maintaining the homeostasis of gut, and new mechanisms are being discovered each year. The failed clinical study and negative results of probiotic treatment may propose the customized probiotic design for treatment. For probiotic supplement products in the market, upgrading are strongly suggested from aspects of formula innovation and clinically referred probiotic dosage.
Source: Trends in Food Science and Technology - Category: Food Science Source Type: research