Yale designated as Parkinson ’s Foundation Research Center

The Yale School of Medicine is among four institutions that will receive $2 million over five years to “advance Parkinson’s disease research towards a cure.”
Source: Yale Science and Health News - Category: Universities & Medical Training Source Type: news

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Contributors : Tim Ahfeldt ; Lee RubinSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensPurpose of NGS transcriptomics: We generated RNA-sequencing transcriptomics datasets from isogenic Parkinson ’s disease (PD) HUES1 cell lines (harboring loss of function mutations in either PARKIN (PRKN), DJ-1-/- (PARK7), or ATP13A2-/- (PARK9)) to identify common and distinct dysregulated genes and networks in our three isogenic PD lines in an unbiased way, with the goal of grouping similar and distinct forms of PD and identify common or divergent dysregulation.
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
Depression and anxiety are common neuropsychiatric manifestations of Parkinson disease. However, they are often under-recognized because the somatic symptoms of depression often overlap with the motor symptoms of Parkinson disease and there is low self-rep...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Elder Adults Source Type: news
Publication date: Available online 18 November 2019Source: NeuroImage: ClinicalAuthor(s): Yi-Ai Rau, Shi-Ming Wang, Jacques-Donald Tournier, Sung-Han Lin, Chin-Song Lu, Yi-Hsin Weng, Yao-Liang Chen, Shu-Hang Ng, Shao-Wen Yu, Yi-Ming Wu, Chih-Chien Tsai, Jiun-Jie WangAbstractIntroduction: Disruption to white matter pathways is an important contributor to the pathogenesis of Parkinson's disease. Fixel-based analysis has recently emerged as a useful fiber-specific tool for examining white matter structure. In this longitudinal study, we used Fixel-based analysis to investigate white matter changes occurring over time in patie...
Source: NeuroImage: Clinical - Category: Radiology Source Type: research
PARKINSON ’S disease is a progressive neurological condition that can make daily tasks difficult for the person affected. While there is no cure for the condition, spotting the warning signs can help to slow down the symptoms, and one early warning sign to watch out for is changes in your handwriting.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
The worst possible outcome when developing a clinical therapy is not an early failure. It is a late failure, in the final and most expensive phase III clinical trial, in which the therapy interacts with a sizable patient population, and after a great deal of time and funding have been devoted to the program. This result is far more likely for therapies based on mechanisms that have smaller rather than larger effect sizes, and where that smaller effect size varies from individual to individual for reasons that are not well understood - something that describes all too much of the past few decades of efforts to treat age-rel...
Source: Fight Aging! - Category: Research Authors: Tags: Medicine, Biotech, Research Source Type: blogs
Condition:   Parkinson's Disease Interventions:   Drug: FB-101;   Drug: Placebo Sponsor:   1ST Biotherapeutics, Inc. Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
BACKGROUND: In addition to motor deficits, Parkinson's disease (PD) may cause perceptual impairments. The role of perceptual impairments in sensorimotor function is unclear, and has typically been studied in single-joint motions. RESEARCH QUESTION: We hypo...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Elder Adults Source Type: news
We looked at the non-clinical impacts of multiple sclerosis (MS) on the individual with MS, their carers and wider society, focusing on disease progression. We used a rapid evidence assessment and key informant interviews.
Source: RAND Research Health and Health Care - Category: Health Management Authors: Source Type: research
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter, please visit: https://www.fightaging.org/newsletter/ Longevity Industry Consulting Services Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
In recent years, multiple lines of evidence from human genetic and molecular studies have highlighted the importance of the autophagy lysosomal pathway (ALP) in Parkinson's disease (PD). Genes such as GBA and LRRK2, which harbor some of the most common mutations associated with PD, have essential roles in the ALP. α-synuclein, encoded by the SNCA gene, is degraded mainly by the ALP, and mutations/multiplications in SNCA may lead to impairment of chaperone mediated autophagy or other ALP functions.
Source: Parkinsonism and Related Disorders - Category: Neurology Authors: Source Type: research
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