The N-Degron Pathway Mediates ER-phagy

Ji et  al. show that the N-degron pathway mediates ER-phagy for ER protein quality control, initiated by the interaction of the autophagic cargo adaptor p62 and the transmembrane E3 ligase TRIM13. Ubiquitination of TRIM13 and the N-terminal arginine residue of N-degron substrates such as BiP/GRP78 functi on as ER-phagy degrons.

Source: Molecular Cell - July 29, 2019 Category: Cytology Authors: Chang Hoon Ji, Hee Yeon Kim, Ah Jung Heo, Su Hyun Lee, Min Ju Lee, Su Bin Kim, Ganipisetti Srinivasrao, Su Ran Mun, Hyunjoo Cha-Molstad, Aaron Ciechanover, Cheol Yong Choi, Hee Gu Lee, Bo Yeon Kim, Yong Tae Kwon Tags: Article Source Type: research