Young adults diagnosed with high grade gliomas: Patterns of care, outcomes, and impact on employment

Publication date: Available online 29 July 2019Source: Journal of Clinical NeuroscienceAuthor(s): Umbreen Hafeez, Siddarth Menon, Bella Nguyen, Caroline Lum, Gregory Gaughran, Ganesalingham Pranavan, Lawrence Cher, Anna K. Nowak, Hui K. Gan, Sagun ParakhAbstractThere is limited information on the patterns of care and outcomes of high grade gliomas (HGGs) in young adults, in particular, the impact it has on a person’s employment. We retrospectively identified young adult patients (age ≤ 40 years old) with newly diagnosed high grade gliomas treated between January 2013 and June 2018 across four major neuro-oncology centres in Australia. Patient demographics, tumour characteristics and treatment parameters were collected and outcomes determined. A total of 113 patients were identified with a median follow up of 27.0 months (range 1.0–70.2 months). The median age was 31 years, majority were male (65%) and employed (71.6%). IDH mutations were detected in 66 (62%) cases. The median progression-free survival (PFS) was 38.0 months (95% CI 23.3–52.7 months) and median overall survival (OS) was not reached. Patients with IDH wild type anaplastic astrocytoma and glioblastoma had a significantly shorter median PFS (19.3 months vs. NR, p = 0.001) and median OS (43.5 months vs NR, p = 0.007) than those with IDH mutated grade III anaplastic astrocytoma and oligodendroglioma. There was no significant difference in median OS or PFS between patients who unde...
Source: Journal of Clinical Neuroscience - Category: Neuroscience Source Type: research