Diffusing Capacity of Carbon Monoxide in Assessment of Chronic Obstructive Pulmonary Disease.

Diffusing Capacity of Carbon Monoxide in Assessment of Chronic Obstructive Pulmonary Disease. Chest. 2019 Jul 25;: Authors: Balasubramanian A, MacIntyre NR, Henderson RJ, Jensen RL, Kinney G, Stringer WW, Hersh CP, Bowler RP, Casaburi R, Han MK, Porszasz J, Barr RG, Make BJ, Wise RA, McCormack MC Abstract BACKGROUND: Diffusing capacity of the lung for carbon monoxide (DLCO) is inconsistently obtained in patients with chronic obstructive pulmonary disease (COPD) and the added benefit of DLCO testing beyond more common tools is unknown. OBJECTIVE: To determine whether lower DLCO is associated with increased COPD morbidity independent of spirometry and CT emphysema. METHODS: Data for 1806 COPD participants from the COPDGene 5-year visit were analyzed, including pulmonary function testing, quality of life, symptoms, exercise performance, and exacerbation rates. DLCO % predicted was primarily analyzed as a continuous variable and additionally categorized into four groups: (1) DLCO and FEV1>50% (reference), (2) only DLCO ≤50%, (3) only FEV1 ≤50%, and (4) both ≤50% predicted. Outcomes were modelled using multivariable linear and negative binomial regression, including emphysema and FEV1 % predicted among other confounders. RESULTS: In multivariable analyses, every 10% predicted decrease in DLCO was associated with symptoms and quality of life (CAT: 0.53 p
Source: Chest - Category: Respiratory Medicine Authors: Tags: Chest Source Type: research

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Source: Current Opinion in Pulmonary Medicine - Category: Respiratory Medicine Tags: OBSTRUCTIVE, OCCUPATIONAL AND ENVIRONMENTAL DISEASES: Edited by Manish Joshi and Basil Varkey Source Type: research
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