Amelioration of perivascular adipose inflammation reverses vascular dysfunction in a model of non-obese prediabetic metabolic challenge: Potential role of anti-diabetic drugs

The onset of vascular impairment precedes that of diagnostic hyperglycemia in diabetic patients suggesting a vascular insult early in the course of metabolic dysfunction without a well-defined mechanism. Mounting evidence implicates adipose inflammation in the pathogenesis of insulin resistance and diabetes. It is not certain whether amelioration of adipose inflammation is sufficient to preclude vascular dysfunction in early stages of metabolic disease. Recent findings suggest that anti-diabetic drugs, metformin and pioglitazone, improve vascular function in prediabetic patients, without an indication if this protective effect is mediated by reduction of adipose inflammation.

Source: Translational Research - July 28, 2019 Category: Research Authors: Mohammed A.W. Elkhatib, Ali Mroueh, Rim W. Rafeh, Fatima Sleiman, Hosny Fouad, Evan I. Saad, Mohamed A. Fouda, Ola Elgaddar, Khodr Issa, Ali H. Eid, Assaad A. Eid, Khaled S. Abd-Elrahman, Ahmed F. El-Yazbi Source Type: research