Gene plays role in early-onset heart disease and diabetes

Yale investigators have found that a gene called CELA2A is common to families with multiple members who have, or are at risk for, early-onset heart disease.
Source: Yale Science and Health News - Category: Universities & Medical Training Source Type: news

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[Ghanaian Times] I have devoted the last few days to sharing information on diabetes. The feedbacks have been good. There was one that I would like to share with you, dear reader.Can diabetes on its own cause heart disease in a person? The response is yes. There is actually a condition known as diabetic cardiomyopathy.
Source: AllAfrica News: Health and Medicine - Category: African Health Source Type: news
In conclusion, high-dose NR induces the onset of WAT dysfunction, which may in part explain the deterioration of metabolic health. Towards a Rigorous Definition of Cellular Senescence https://www.fightaging.org/archives/2019/11/towards-a-rigorous-definition-of-cellular-senescence/ The accumulation of lingering senescent cells is a significant cause of aging, disrupting tissue function and generating chronic inflammation throughout the body. Even while the first senolytic drugs capable of selectively destroying these cells already exist, and while a number of biotech companies are working on the productio...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
(Society for Endocrinology) While weight-loss surgeries are not usually performed in people above the age of 65, a new study shows that these procedures can lead to successful weight loss and better diabetes control in older adults. The study, presented at the Society for Endocrinology annual conference in Brighton, UK, indicates that elderly patients treated with bariatric surgery (gastric bypass or gastric sleeve) can recover well and have a reduced risk of obesity-related complications, including heart disease and diabetes.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
(Reuters Health) - Severely injured patients are more likely to have complications or die if they have a cluster of cardiovascular risk factors like high blood pressure, diabetes and obesity, a recent study suggests.
Source: Reuters: Health - Category: Consumer Health News Tags: healthNews Source Type: news
There is evidence to suggest that frequent use of the sweeteners, especially in diet sodas, raises the risk of several chronic diseases, including obesity, metabolic syndrome, type 2 diabetes, and heart disease.
Source: WebMD Health - Category: Consumer Health News Source Type: news
Cardiovascular diseases are the leading cause of morbidity and mortality in the world. Diabetes increase heart disease related to death by two- to four-fold. SGLT2 inhibitors are new antidiabetic agents. The growing evidence of cardiovascular benefit of SGLT2 inhibitors independent of their effects on glycemic control is especially intriguing. Several clinical trials have shown that sotagliflozin (SGLT1-1/2 inhibitor) decreases body weight and reduces blood pressure in adults with T2D. A phase 3 study designed to evaluate cardiovascular outcomes of sotagliflozin is currently ongoing. Many pre-clinical studies were conducte...
Source: Cardiovascular Endocrinology - Category: Cardiology Tags: Review Articles Source Type: research
CONCLUSIONS AND IMPLICATIONS FOR PUBLIC HEALTH PRACTICE: Efforts that prevent adverse childhood experiences could also potentially prevent adult chronic conditions, depression, health risk behaviors, and negative socioeconomic outcomes. States can use comprehensive public health approaches derived from the best available evidence to prevent childhood adversity before it begins. By creating the conditions for healthy communities and focusing on primary prevention, it is possible to reduce risk for adverse childhood experiences while also mitigating consequences for those already affected by these experiences. PMID: 316...
Source: MMWR Morb Mortal Wkl... - Category: Epidemiology Authors: Tags: MMWR Morb Mortal Wkly Rep Source Type: research
Abstract Orthostatic hypotension (OH) is a cardinal sign of cardiovascular (CV) autonomic dysfunction as a result of autonomic nervous system failure to control the postural hemodynamic homeostasis. The proportion of individuals with OH increases with aging and chronic conditions, such as neurodegenerative diseases, hypertension, heart failure, diabetes, renal dysfunction, autoimmune diseases and cancer. In those over 70 years, more than 20% can be affected. It is now increasingly recognized that a direct relationship exists between OH and each step of the CV disease continuum, eventually leading to end-stage hear...
Source: Polish Heart Journal - Category: Cardiology Authors: Tags: Kardiol Pol Source Type: research
A diet high in added sugar, impossible to escape in processed foods, has been linked to diabetes, heart disease and possibly cancerThere ’s a delectable scene in André Aciman’s latest novelFind Me where three characters sit down to lunch. They have just purchased fresh fish and scallops from the market, plus spinach and wine. On a balcony overlooking Rome, the woman “split open thebranzinishe had broiled in a cast-iron frying pan, removed their bones, and on a different plate came the spinach and oldpuntarelle, over which, once we were seated, she sprinkled oil and freshly grated parmesan ”.R...
Source: Guardian Unlimited Science - Category: Science Authors: Tags: Food Sugar Health & wellbeing Science Source Type: news
This international randomised controlled trial evaluated whether COPD patients with comorbidities, trained in using patient-tailored multidisease exacerbation action plans, had fewer COPD exacerbation days than usual care (UC). COPD patients (Global Initiative for Chronic Obstructive Lung Disease (GOLD) classification II–IV) with ≥1 comorbidity (ischaemic heart disease, heart failure, diabetes, anxiety, depression) were randomised to a patient-tailored self-management intervention (n=102) or UC (n=99). Daily symptom diaries were completed for 12 months. The primary outcome "COPD exacerbation days per pat...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: COPD and smoking Original Articles: COPD Source Type: research
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