Mesenchymal stem cells and IL-37: a powerful combination.
Mesenchymal stem cells and IL-37: a powerful combination.
J Biol Regul Homeost Agents. 2019 Jul-Aug;33(4):1019-1022
Authors: Gugliandolo A, Caraffa AL, Gallenga CE, Kritas SK, Ronconi G, Trubiani O, Conti P, Di Emidio P, Mazzon E
Abstract
Mesenchymal stem cells (MSCs) are able to exert immunomodulatory and anti-inflammatory actions. Thanks to these properties, MSCs may be a promising alternative approach for the treatment of inflammatory disease. Important cytokines involved in inflammation are those included in the IL-1 family. Interleukin-37 (IL-37) is one of the member able to suppress both innate and adaptive immunity. Recently, it was found that MSCs and their derivatives can modulate IL-37, and MSCs expressing IL-37 seem to have an enhanced therapeutic efficacy.
PMID: 31347346 [PubMed - in process]
Source: Journal of Biological Regulators and Homeostatic Agents - Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research