What Is the Role of Imaging at Primary Diagnostic Work-Up in Uterine Cervical Cancer?

AbstractPurpose of ReviewFor uterine cervical cancer, the recently revised International Federation of Gynecology and Obstetrics (FIGO) staging system (2018) incorporates imaging and pathology assessments in its staging. In this review we summarize the reported staging performances of conventional and novel imaging methods and provide an overview of promising novel imaging methods relevant for cervical cancer patient care.Recent FindingsDiagnostic imaging during the primary diagnostic work-up is recommended to better assess tumor extent and metastatic disease and is now reflected in the 2018 FIGO stages 3C1 and 3C2 (positive pelvic and/or paraaortic lymph nodes). For pretreatment local staging, imaging by transvaginal or transrectal ultrasound (TVS, TRS) and/or magnetic resonance imaging (MRI) is instrumental to define pelvic tumor extent, including a more accurate assessment of tumor size, stromal invasion depth, and parametrial invasion. In locally advanced cervical cancer, positron emission tomography-computed tomography (PET-CT) or computed tomography (CT) is recommended, since the identification of metastatic lymph nodes and distant metastases has therapeutic consequences. Furthermore, novel imaging techniques offer visualization of microstructural and functional tumor characteristics, reportedly linked to clinical phenotype, thus with a potential for further improving risk stratification and individualization of treatment.SummaryDiagnostic imaging by MRI/TVS/TRS and PET...
Source: Current Oncology Reports - Category: Cancer & Oncology Source Type: research

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Authors: Brenner DR, Ruan Y, Shaw E, O'Sullivan D, Poirier AE, Heer E, Villeneuve PJ, Walter SD, Friedenreich CM, Smith L, De P Abstract BACKGROUND: Although cancer incidence over time is well documented in Canada, trends by birth cohort and age group are less well known. We analyzed age- and sex-standardized incidence trends in Canada for 16 major cancer sites and all cancers combined. METHODS: We obtained nationally representative population-based cancer incidence data in Canada between 1971 and 2015 from the National Cancer Incidence Reporting System (1969-1992) and the Canadian Cancer Registry (1992-2015). ...
Source: Canadian Medical Association Journal - Category: General Medicine Tags: CMAJ Source Type: research
Publication date: Available online 11 November 2019Source: Gynecologic Oncology ReportsAuthor(s): Yingao Zhang, Megan S. Grant, Wesley H. Stepp, Leslie H. ClarkAbstractThe development of brain and central nervous system (CNS) metastases from primary gynecologic cancers is an extremely uncommon but deadly process. Through this retrospective case series of patients treated at a single institution from 2004 to 2018, we aim to explore potential clinical patterns of this phenomenon with respect to primary tumor type, histology, and symptomatology.A total of 42 patients were identified with CNS metastases, with 24 patients havin...
Source: Gynecologic Oncology Reports - Category: OBGYN Source Type: research
Discussion and conclusionThe Authors, as a result of the present study, suggest that office hysteroscopy should be sussessful at the first attempt, because the majority of patients (58%), in case of a failed procedure, do not undergo a repeat hysteroscopy in a reasonable time and important diagnosis, such as that of endometrial cancer, may be missed or delayed. In order to increase the procedure success rate, prior to the scheduled hysteroscopy they recommend to counsel all patients, identifying those who may benefit from pharmacological cervical softening, local anesthetic injection or the use of small caliber hysteroscopes.
Source: European Journal of Obstetrics and Gynecology and Reproductive Biology - Category: OBGYN Source Type: research
Pathologically confirmed brain metastasis from primary cervical cancer is extremely rare. Herein, we report two cases of intracranial metastasis from cervical cancer that were histopathologically confirmed aft...
Source: World Journal of Surgical Oncology - Category: Cancer & Oncology Authors: Tags: Case report Source Type: research
In this study, we demonstrate that HPV E6 is ubiquitinated by E6AP in presence of p53. Crucially, ubiquitination of E6 is important for p53 degradation and blockage of E6 ubiquitination negatively interferes with E6-mediated p53 degradation and enhances the apoptotic effects of p53 and the cytotoxicity of DNA damage in HPV-positive cervical cancer cells. Importantly, our data suggest that the HPV oncogene E6 might be an optimal pharmacologic.
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
This study aims to assess factors associated with depressive symptoms in older women with gynecologic cancers and to examine the association of depression with health-related quality of life (HRQOL).Materials and methodsWomen aged 65 and older previously diagnosed with cervical, ovarian, or uterine cancer (n=1977) were identified from the Surveillance, Epidemiology, and End Results – Medicare Health Outcomes Survey database and compared to propensity-matched cancer-free controls (n=9885). Women with and without depressive symptoms were compared by cancer status. Logistic regression was used to identify factors associ...
Source: Journal of Geriatric Oncology - Category: Cancer & Oncology Source Type: research
ConclusionsAs far as we are aware, this is the first report of papillary squamotransitional cell carcinoma of the uterine cervix metastatic to the ovary without vaginal bleeding and with a clinically and radiologically unsuspicious cervix. Physicians should always contemplate papillary squamotransitional cell carcinoma of the uterine cervix in unclear cases with ovarian metastasis, especially if the histology indicates a transitional cancer (CK7+ and CK20−), before proceeding with treatment. More cases are needed to illuminate the clinical characteristics and categorization of papillary squamotransitional cell carcin...
Source: Journal of Medical Case Reports - Category: General Medicine Source Type: research
Publication date: Available online 24 October 2019Source: Gynecologic Oncology ReportsAuthor(s): Caroline J. Violette, Rachel S. Mandelbaum, David J. Nusbaum, Christina J. Duval, Shinya Matsuzaki, Hiroko Machida, Lynda D. Roman, Koji MatsuoAbstractObjectiveTo examine the trends, characteristics, and outcomes of women with gynecologic malignancies who died of suicide in the United States.MethodsThis is a retrospective, observational study using the Surveillance, Epidemiology and End Results program from 1973-2013. Women with uterine, ovarian, and cervical cancers who had cause of death recorded as suicide or self-inflicted ...
Source: Gynecologic Oncology Reports - Category: OBGYN Source Type: research
ConclusionLymph node metastases, LVSI and surgical border involvement are independent prognostic factors for PI in early stage cervical cancer patients. Therefore, less radical surgical approaches for early stage tumors with no nodal spread, negative LVSI and no surgical border involvement are applicable.
Source: European Journal of Obstetrics and Gynecology and Reproductive Biology - Category: OBGYN Source Type: research
Cancer of the uterine cervix is among the most preventable human malignancies, yet it remains a leading cause of death among women worldwide, accounting for more than 300  000 deaths annually. Well on its way to elimination in the global north, cervical cancer mostly affects women living in low- or middle-income countries (LMICs), where limited access to vaccination, screening, and therapy have made it overwhelmingly a disease of women who are poor and lack access to health care. Nowhere is this more evident than in sub-Saharan Africa, where HIV is endemic and where cervical cancer has surpassed breast cancer as the most...
Source: JAMA - Category: General Medicine Source Type: research
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