White Matter in Schizophrenia Treatment Resistance
American Journal of Psychiatry, Ahead of Print.
In conclusion, this study found that patients with FES had abnormal functional connectivity in the amygdala subregions, and the altered rsFC was associated with positive symptoms. The present findings demonstrate the disruptive rsFC patterns of amygdala subregional-sensorimotor networks in FES and may provide new insights into the neuronal pathophysiology of FES.
Severe infection is linked to an increased risk of substance-induced psychosis. However, hepatitis is the most strongly linked and the only infection tied to schizophrenia conversion.Medscape Medical News
Conclusion This study shows meaningful clinical effectiveness and good tolerability of mECT in patients with resistant schizophrenia over extended periods.
Objective The aim of this study was to report the efficacy and safety of electroconvulsive therapy (ECT) in manic, depressed, psychotic, and catatonic adolescent patients. Methods Medical records of 78 adolescents who had received ECT in Department of Psychiatry, Gaziantep University Medical Faculty, during 2011 to 2017 were reviewed. Sixty-two subjects in this sample were identified to have complete records and met the study inclusion criteria. Results The mean ± SD age of subjects was 17.11 ± 1.04 years and female sex was 53.2% (n = 33). Primary the Diagnostic and Statistical Manual of Mental Disord...
No abstract available
AbstractNicotinic acetylcholine receptors (nAChRs) are major signalling molecules in the central and peripheral nervous system. Over the last decade, they have been linked to a number of major human psychiatric and neurological conditions, like smoking, schizophrenia, Alzheimer's disease, and many others. Human Genome ‐Wide Association Studies (GWAS) have robustly identified genetic alterations at a locus of chromosome 15q to several of these diseases. In this review, we discuss a major coding polymorphism in the alpha5 subunit, referred to as α5SNP, and its functional dissectionin vitro andin vivo. Its presence at...
Several studies have found that patients with schizophrenia experience cognitive benefits from exercise. Astudy inPsychiatric Research suggests schizophrenia patients who participate in a 12-week aerobic exercise program may continue to experience cognitive benefits months after the program ends.“These findings encourage the incorporation of [aerobic exercise] in psychosocial treatment regimens [for schizophrenia],” wrote Takeshi Shimada, Ph.D., of the Medical Corporation Seitaikai Mental Support Soyokaze Hospital in Japan and colleagues.Shimada and colleagues conducted a randomized trial in which patients were...
Condition: Schizophrenia Intervention: Other: Evoked Related Potentials Sponsor: Centre Hospitalier Universitaire de Nice Not yet recruiting
Condition: Schizophrenia Intervention: Behavioral: Cognitive Remediation Therapy Sponsors: Hospital Clinic of Barcelona; National Alliance for Research on Schizophrenia and Depression; Instituto de Salud Carlos III Active, not recruiting
Condition: Schizophrenia; Psychosis Intervention: Drug: Levetiracetam 500 mg Sponsor: Vanderbilt University Medical Center Not yet recruiting