A miniaturized device for biomembrane permeation analysis.

In this study, we fabricated miniaturized multichannel devices (MCDs) by 3D printing, to minimize the use of skin and drug samples. The MCDs were compared with conventional static diffusion cells and achieved comparable drug permeation profiles. The finite element method-based simulation revealed the efficient carry-off of permeated ingredients by the multichannel devices, and a critical role of distance between the buffer stream and skin sample in determining the flow velocity inside the chamber. The results support these devices as qualified alternatives to Franz cells for in vitro permeation studies using biomembranes, with reduced use of skin and drug samples.
PMID: 31349518 [PubMed - in process]

Source: Appl Human Sci - July 29, 2019 Category: Physiology Authors: Ding D, Pan J, Yeo SH, Wagholikar V, Lim SH, Wu C, Fuh JYH, Kang L Tags: Mater Sci Eng C Mater Biol Appl Source Type: research