Effect of knock out of the ASIC3 on cardiovascular reflexes arising from hindlimb muscle in decerebrated rats.

Effect of knock out of the ASIC3 on cardiovascular reflexes arising from hindlimb muscle in decerebrated rats. Am J Physiol Regul Integr Comp Physiol. 2019 Jul 26;: Authors: Kim JS, Harms JE, Ruiz-Velasco VV, Kaufman MP Abstract The exercise pressor reflex is initiated by the contraction-induced activation of group III and IV muscle afferents. The reflex is manifested by increases in arterial blood pressure and cardiac output, which, in turn, are generated by increases in the sympathetic outflow to the heart and vasculature and decreases in the vagal outflow to the heart. In previous experiments, we used a pharmacological approach to assess the role played by the Acid-Sensing Ion Channel 3 (ASIC3) on group III and IV afferents in evoking the exercise pressor reflex. In the present experiments, we used an alternative approach, namely functional knock out of the ASIC3 gene to confirm and extend our previous finding that pharmacological blockade of the ASIC3 had only a small impact on the expression of the exercise pressor reflex when the arterial supply to the contracting hind limb muscles of rats was patent. Using this alternative approach, we compared the magnitude of the exercise pressor reflex evoked in ASIC3 knock out (KO) rats with that evoked in their wild type (WT) counterparts. We found both WT and ASIC3 KO rats displayed similar pressor responses to static contraction and calcaneal tendon stretch. Likewise, both WT and ASIC3 ...
Source: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology - Category: Physiology Authors: Tags: Am J Physiol Regul Integr Comp Physiol Source Type: research