Towards a surrogate system to express human lipid binding TCRs.

CONCLUSIONS: The results suggest that the mis-pairing of the endogenous α/β TCR during ER folding in the presence of the new human TCR sequences could be impairing the functionality of the TCR lipid receptors. The surrogate systems presented here are important first steps in the establishment of human cell-specific lipid responsive libraries for the study of natural lipid substances.
PMID: 31346817 [PubMed - as supplied by publisher]

Source: Biotechnology Letters - July 25, 2019 Category: Biotechnology Authors: Wang R, Pscheid R, Ghumra A, Kan LYL, Cochrane S, Fairclough L, Alcocer MJC Tags: Biotechnol Lett Source Type: research