Science Behind Elecroacupuncture for Treating Shingles

Conclusions: EA treatment improves thermal perception by recovering TRPV1-positive sensory neuronsand nerve terminals damaged by RTX. EA Also reduces RTX-induced tac tile allodynia by attenuating the damage of myelinated afferent nerves and their abnormal sprouting into the spinal lamina II. Our study provides new information about the mechanisms of the therapeutic actions of EA in the treatment of PHN. Figure 2:  Effect of EA on RTX-induced deletion of TRPV1-immunoreactive neuron s in the DRG. A, Representative images showing TRPV1-immunoreactive neurons in the lumbar DRG of vehicle ( a ) , RTX ( b ), RTX plus 2 Hz EA ( c ), RTX plus 15 Hz EA ( d ), RTX plus 100 Hz EA ( e ), and RTX plus sham EA ( f ) groups. Scale bar, 50 μ m. B, Summary data show the number of TRPV1 immunoreactive neurons in different groups. Data are expresse d as means ± SEM (n = 6 rats in each group). *P < 0.05, compared with the vehicle group; # P< 0.05, compared with the sham EA group. Figure 3: Effect of EA on RTX-induced deletion of TRPV1 immunoreactive central terminals in the spinal dorsal horn. A, Representative images showing TRPV1 immunoreactive central terminals of afferent fibers in the spinal dorsal horn of vehicle (a) ,RTX (b), RTX plus 2 Hz EA (c), RTX plus 15 Hz EA (d), RTX plus 100 Hz EA (e), and RTX plus sham EA (f) groups. Scale bar, 50 μm. B, Summary data show the area of TRPV1 immunoreactive central terminals in different groups. Data are expressed as means ±...
Source: Neuromics - Category: Neuroscience Tags: TRPV1 antibodies Immunhistochemistry postherpetic neuralgia Dorsal Root Ganglia Dorsal horn shingles TRPV1-N Antibody Immunfluorescence VR1-N Antibody Source Type: news