Clinical Phenotypes, Comorbidities, and Exacerbations according to Serum 25-OH Vitamin D and Plasma Fibrinogen Levels in Chronic Obstructive Pulmonary Disease.

CONCLUSION: Our findings suggested an interaction between vitamin D deficiency and COPD. The measurement of plasma fibrinogen concentrations could help identify a severe phenotypic group among patients with vitamin D deficiency. PMID: 31347309 [PubMed - in process]
Source: J Korean Med Sci - Category: General Medicine Authors: Tags: J Korean Med Sci Source Type: research

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Introduction: In last few years, many studies have shown the impact of vitamin D deficiency in COPD exacerbation. We conducted this retrospective study in 90 COPD patients who presented with exacerbation due to various reasons to our hospital. We analysed, if vitamin D (2,5 OHD) deficiency of less then 30 ng/ml is associted with infective exacerbation of COPD.Method: Out of 90 COPD patients, 66 were males and 24 were females. Range of age was from 48 to 83 years. 64 out of 90 were active smokers at the time of presentation.The reason of exacerbation were established in every patient. Those, with increase in purulence of sp...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Airway pharmacology and treatment Source Type: research
Background: Osteoporosis is an important extra-pulmonary manifestation of chronic obstructive pulmonary disease (COPD).Aim: To evaluate the prevalence of osteoporosis, osteopenia and vitamin D deficiency in patients with moderate to very severe COPD, and to explore the association between bone mineral density (BMD) and exercise capacity / gait speed.Methods: BMD and T-score were measured by the dual energy X-ray absorptiometry, and serum level of 25-hydroxyvitamin D was determined. Severity of COPD was evaluated by the pulmonary functions tests, COPD Assessment Test, and modified Medical Research dyspnoea scale. Six-minute...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Monitoring airway disease Source Type: research
Conclusions: Importantly, lung function in both the groups was affected by decreased vitamin D level; decrease in FEV1 was more pronounced among COPD patients compared to controls showing more expiratory airflow limitation. Vitamin D levels are associated with changes in lung function in cases of COPD as well as healthy controls. Larger studies to confirm the association in Indian context are required and routine assessment of vitamin D may be undertaken to obviate the effects of low vitmain D level on lung function.
Source: Lung India - Category: Respiratory Medicine Authors: Source Type: research
Authors: Chen FY, Xiao M, Ling B, Liu L, Chen L Abstract OBJECTIVE: Vitamin D deficiency plays an important role in chronic obstructive pulmonary disease (COPD). However, the effects of vitamin D supplementation on lung function decline in COPD were inconsistently reported and a meta-analysis is thus needed. MATERIALS AND METHODS: Eligible cohort and randomized controlled trials (RCTs) were searched from databases including PubMed, Embase, and Web of Science. Pooled standardized mean difference (SMD) with 95% confidence interval (CI) was calculated in a random or fixed effects model. RESULTS: Eight studies ...
Source: European Review for Medical and Pharmacological Sciences - Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
Authors: Dastan F, Salamzadeh J, Pourrashid MH, Edalatifard M, Eslaminejad A Abstract Chronic Obstructive Pulmonary Disease (COPD) is associated with increased inflammatory responses to noxious particles, which can be further enhanced during Acute Exacerbation of COPD (AECOPD). Considering the important immunoregulatory function of vitamin D, high prevalence of Vitamin D Deficiency (VDD) in COPD patients and a negative link between vitamin D levels and inflammatory biomarkers, suggests the seemingly interesting mechanism of vitamin D effects on inflammation resolution during the conventional treatment of AECOPD. Th...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - Category: Respiratory Medicine Tags: COPD Source Type: research
This study analyzed the correlations among COPD, vitamin D concentration, and epithelial-mesenchymal transition (EMT). Ninety-five patients with newly diagnosed COPD and 190 age- and sex-matched healthy subjects were recruited for this research. Serum 25(OH)D levels were detected, and pulmonary EMT biomarkers and TGF-β/Smad signaling were evaluated. Serum 25(OH)D level was remarkably decreased in COPD patients compared with that in control subjects. Furthermore, serum 25(OH)D concentration gradually decreased in COPD patients ranging from grade 1-2 to 4. However, reduced expression of the epithelial biomarker E-cadher...
Source: Journal of Immunology - Category: Allergy & Immunology Authors: Tags: J Immunol Source Type: research
AbstractPatients with respiratory diseases such as cystic fibrosis, chronic obstructive pulmonary disease, or asthma often experience an acute worsening of respiratory symptoms, termed exacerbations. Although the course of exacerbations is disease specific, they are mostly triggered by a respiratory infection. Exacerbations often require hospitalization and are an important cause of mortality. Treatments of exacerbations aim to minimize the negative impact and to prevent subsequent events. Despite many existing therapy options, many patients do not benefit from therapy and suffer from recurrent events. Vitamin D deficiency...
Source: Calcified Tissue International - Category: Orthopaedics Source Type: research
Condition:   Chronic Obstructive Pulmonary Disease Interventions:   Drug: cholecalciferol;   Drug: Placebo oral capsule Sponsor:   Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
In this study they also showed PTX3 localized in NETs formed after neutrophil activation (5). Proteomics analysis revealed that PTX3 forms complexes with two anti-microbial proteins [azurocidin (AZU1) and myeloperoxidase (MPO)] associated to NETs (30). More recently, PTX3 localization in NETs has been confirmed, and the colocalization with AZU1 and MPO has been defined more accurately (31). Further investigation will be needed to understand the involvement of PTX3 interaction with AZU1 and MPO in their antibacterial role during NET formation. Regulation of Complement Activation PTX3 interaction with microorganisms is not...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Condition:   Asthma-COPD Overlap Syndrome Interventions:   Drug: Cholecalciferol;   Other: Placebo oral capsule Sponsor:   Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh Completed
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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