Effect of Hyperglycemia on Myocardial Perfusion in Diabetic Porcine Models and Humans.

Effect of Hyperglycemia on Myocardial Perfusion in Diabetic Porcine Models and Humans. J Korean Med Sci. 2019 Jul 29;34(29):e202 Authors: Park JJ, Kim SH, Kim MA, Chae IH, Choi DJ, Yoon CH Abstract BACKGROUND: Diabetes mellitus (DM) causes macro- and microvasculopathy, but data on cardiac microvascular changes in large animals are scarce. We sought to determine the effect of DM on macro- and microvascular changes in diabetic pigs and humans. METHODS: Eight domestic pigs (4 with type I diabetes and 4 controls) underwent coronary angiography with optical coherence tomography (OCT; at baseline and 1 and 2 months), coronary computed tomography angiography, cardiac magnet resonance (CMR) imaging, and histologic examination. RESULTS: The diabetic pigs had more irregular capillaries with acellular capillaries and a smaller capillary diameter (11.7 ± 0.33 μm vs. 13.5 ± 0.53 μm; P
Source: J Korean Med Sci - Category: General Medicine Authors: Tags: J Korean Med Sci Source Type: research

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