#10 High contrast and resolution labeling of amyloid plaques in tissue sections from APP-PS1 mice and humans with Alzheimer's Disease with the zinc chelator HQ-O: Practical and theoretical considerations.

CONCLUSION: Zinc is intimately bound to all amyloid plaques, which was demonstrated by its histological localization using a novel fluorescent zinc chelator, HQ-O. Additionally, the tracer is also capable of labeling intravascular leucocytes due to their high zinc content.
PMID: 31345150 [PubMed - as supplied by publisher]

Source: Current Alzheimer Research - July 24, 2019 Category: Neurology Authors: Schmued L, Raymick J Tags: Curr Alzheimer Res Source Type: research