Sensors, Vol. 19, Pages 3315: Electrochemiluminescence Sensor Based on Electrospun Three-Dimensional Carbon Nanofibers for the Detection of Difenidol Hydrochloride

Sensors, Vol. 19, Pages 3315: Electrochemiluminescence Sensor Based on Electrospun Three-Dimensional Carbon Nanofibers for the Detection of Difenidol Hydrochloride Sensors doi: 10.3390/s19153315 Authors: Hao Cheng Zhengyuan Zhou Yanqing Li Wenyi Huang Jun Feng Tingfan Tang Lijun Li The detection of difenidol hydrochloride, which is a drug that is widely used for treating the nausea and vomiting symptoms caused by certain diseases, has been increasingly involved in cases of suicide via overdosing and of drug poisoning in children. A novel electrochemiluminescence (ECL) sensor for the simple and effective detection of difenidol hydrochloride was fabricated by modifying a glassy carbon electrode with three-dimensional carbon nanofibers (3D-CNFs). The 3D-CNFs were synthesized by electrospinning a mixture of montmorillonite (MMT) and polyacrylonitrile, carbonizing the electrospun product, and etching it with hydrofluoric acid. The form and structure of the 3D-CNFs was analyzed via scanning electron microscopy, X-ray photoelectron spectroscopy, and Raman microspectroscopy. According to the experimental results obtained using the modified electrodes, a good linear relationship was found between peak intensity and difenidol concentration (y = 868.14x − 61.04, R2 = 0.999), with a relatively low detection limit (8.64 × 10−10 mol·L−1 (S/N = 3)). In addition, our approach exhibited good recovery values ranging from 98...
Source: Sensors - Category: Biotechnology Authors: Tags: Article Source Type: research

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CONCLUSIONS: It is reassuring that the absolute number of prescription drug suicides in non-abusers was small; the findings, however, are important because they could serve as a baseline for assessing time trends in future studies. For the present, we suggest that prescription drugs of potential abuse, especially those containing opioids and antispasmodics, should be prescribed and dispensed judiciously, especially to youth. PMID: 31374376 [PubMed - as supplied by publisher]
Source: Asian Journal of Psychiatry - Category: Psychiatry Tags: Asian J Psychiatr Source Type: research
Authors: Yaylac─▒ F, Küçük Ö, Erkuran HÖ Abstract Paliperidone is a relatively novel atypical antipsychotic drug that is currently used to treat schizophrenia in adolescents and adults. The drug was generated by combining the active metabolite of risperidone, 9-hydroxyrisperidone, with osmotic controlled-release oral administration system (OROS) technology. Due to its specific design, the drug has been identified as a different form, albeit an active metabolite of risperidone. Such distinction mainly manifests itself during pharmacokinetic processes, because paliperidone is not affected b...
Source: Psychopharmacology Bulletin - Category: Psychiatry & Psychology Tags: Psychopharmacol Bull Source Type: research
According to the latest numbers, roughly 9 million Americans — 4% of U.S. adults — use prescription sleep aids, or medications that can help with insomnia and other sleep issues. And now, some of the most popular prescription sleep drugs must carry stronger safety warnings. In April, the Food and Drug Administration (FDA) mandated black-box warnings — which the agency uses to “call attention to serious or life-threatening risks” — on three sedative-hypnotic sleep aids: eszopiclone (often sold under the brand name Lunesta), zaleplon (Sonata) and zolpidem (Ambien). Hypnotic drugs, which ar...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized Drugs Source Type: news
Self-poisoning, which includes drug overdoses – both prescription and over-the-counter- is the most common method in suicide attempts and third-most common method of suicide in teens, the researchers said.
Source: WebMD Health - Category: Consumer Health News Source Type: news
Suicide rates are on the rise in the U.S. across age groups and demographics. But in recent years, increases have been particularly pronounced among teenagers — especially girls, who die by suicide less frequently than boys but attempt it more often. Intentional self-poisoning is the leading type of suicide attempt for adolescents (and the third-leading cause of suicide deaths), and a new study confirms that numbers here, too, are rising. The research, published in the Journal of Pediatrics, found that suicide attempts by poisoning have doubled in frequency among kids younger than 19, rising from almost 40,000 attemp...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized Mental Health/Psychology Source Type: news
We present two patients who were treated for an intentional overdose of sodium nitrite. When ingested sodium nitrite leads to severe methaemoglobinaemia, resulting in severe hypoxia (as methaemoglobin does not transport oxygen), vasodilation and hypotensio...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Poisoning Source Type: news
CONCLUSIONS: Combining national and local approaches to detect suicide may help to improve the classification of suicide deaths in the healthcare setting. PMID: 30877803 [PubMed - as supplied by publisher]
Source: Military Medicine - Category: International Medicine & Public Health Tags: Mil Med Source Type: research
ConclusionThis case demonstrates that in the case of a massive drug consumption, a pharmacobezoar should be suspected, particularly when cellulose-coated pills are ingested. Severe poisoning due to delayed drug release from the gastric aggregate is a potential complication. Detection by x-ray is crucial, and treatment is centered on removal of the aggregate. The technique of decontamination varies among experts, and no formal recommendations exist to date. It seems reasonable that endoscopic evaluation should be performed in order to determine the appropriate technique of decontamination. Care should be patient-oriented an...
Source: Journal of Medical Case Reports - Category: General Medicine Source Type: research
Zach (left) and Bob (right) According to the National Institute on Drug Abuse, more than 70,000 Americans died from drug overdoses in 2017, including illicit drugs and prescription opioids, a two-fold increase in a decade. Opioids include prescription opioids and methadone, heroin, and other synthetic narcotics like fentanyl. Bob Paff has directly suffered the casualties of this epidemic. On January 21 of this year he lost his son Zach to an accidental overdose of fentanyl. A highly sought-after communications expert, business leader, and internationally recognized author, Bob now uses his communications platform to bring ...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Addiction General Recovery Stigma Opioid Epidemic Opioids Suicide synthetic fentanyl Source Type: blogs
BACKGROUND: In the United States, adolescent suicide attempts are increasing. Indiana has the highest rate of adolescent suicidal ideation in the US. Using the National Poison Data System (NPDS), we analyzed Indiana's increase in suicide attempts by poison...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Adolescents Source Type: news
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