Antagonism between Antiviral Signaling and Glycolysis.

Antagonism between Antiviral Signaling and Glycolysis.
Trends Endocrinol Metab. 2019 Jul 23;:
Authors: Chauhan AS, Zhuang L, Gan B
Abstract
RIG-I-like receptor (RLR)-mediated interferon production is critical for antiviral responses. A recent study (Zhang et al., Cell, 2019) uncovered a reciprocal inhibition between RLR signaling and glycolysis: lactate produced by glycolysis inhibits RLR signaling by binding to RLR signaling component mitochondrial antiviral-signaling (MAVS), whereas RLR activation suppresses glycolysis through inhibiting glycolysis enzyme hexokinase.
PMID: 31349923 [PubMed - as supplied by publisher]

Source: Trends in Endocrinology and Metabolism: TEM - July 22, 2019 Category: Endocrinology Authors: Chauhan AS, Zhuang L, Gan B Tags: Trends Endocrinol Metab Source Type: research