Assembling Systems Biology, Embryo Development and Teratogenesis: what do we know so far and where to go next?

Publication date: Available online 27 July 2019Source: Reproductive ToxicologyAuthor(s): Thayne Woycinck Kowalski, Ágata de Vargas Dupont, Bruna Duarte Rengel, Eduarda Sgarioni, Julia do Amaral Gomes, Lucas Rosa Fraga, Lavínia Schuler-Faccini, Fernanda Sales Luiz ViannaAbstractThe recognition of molecular mechanisms of a teratogen can provide insights to understand its embryopathy, and later to plan strategies for the prevention of new exposures. In this context, experimental research is the most invested approach. Despite its relevance, these assays require financial and time investment. Hence, the evaluation of such mechanisms through systems biology rise as an alternative for this conventional methodology. Systems biology is an integrative field that connects experimental and computational analyses, assembling interaction networks between genes, proteins, and even teratogens. It is a valid strategy to generate new hypotheses, that can later be confirmed in experimental assays. Here, we present a literature review of the application of systems biology in embryo development and teratogenesis studies. We provide a glance at the data available in public databases, and evaluate common mechanisms between different teratogens. Finally, we discuss the advantages of using this strategy in future teratogenesis researches.

Source: Reproductive Toxicology - July 28, 2019 Category: Toxicology Source Type: research