Autoimmunity in Common Variable Immunodeficiency.

CONCLUSION: Mechanisms producing these conditions are poorly understood but include cytokine and cellular inflammatory pathways, and loss of tolerance to self-antigens through the multiple signaling molecules and pathways common to tolerance and immune deficiency. PMID: 31349011 [PubMed - as supplied by publisher]
Source: Annals of Allergy, Asthma and Immunology - Category: Allergy & Immunology Authors: Tags: Ann Allergy Asthma Immunol Source Type: research

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Conclusions: the frequencies of infections in maternal-fetal health were considered low, highlighting on syphilis and the presence for sickle cell trait.Resumo Objetivos: estimar a taxa de detec ção de patologias da TPN em papel de filtro nas regiões Sul e Sudoeste do Estado da Bahia, bem como delinear o perfil epidemiológico dessas gestantes, calcular e estimar a taxa de adesão e abrangência de cobertura do Programa. Métodos: estudo descritivo, de agosto 2013 a agosto de 2015, de d ados obtidos do Labimuno/ICS/UFBA. Resultados: foram incluídas 64.743 gestantes; as m&e...
Source: Revista Brasileira de Saude Materno Infantil - Category: Midwifery Source Type: research
We report a case of a neglected foreign body present in the bronchus of an adult for 23 years and treated as intermittent asthma. The diagnosis was revealed following the development of severe sepsis of a pulmonary origin. The foreign body was removed by rigid bronchoscopy, antibiotic therapy instituted and pre- and post-interventional respiratory physiotherapy carried out. Satisfactory progress was marked by the complete clearing of pulmonary suppuration, with only a small localized and asymptomatic focus of bronchial dilatation remaining. The persistence of chronic, unexplained respiratory complaints should prompt t...
Source: Revue des Maladies Respiratoires - Category: Respiratory Medicine Tags: Rev Mal Respir Source Type: research
Authors: Taytard J, Boizeau P, Alberti C, Beydon N Abstract INTRODUCTION: The reference technique to measure the diffusing capacity of the lung for carbon monoxide (DLco) is the single-breath method (sb). For patients unable to perform this method, the rebreathing method (rb) can be used. However, the clinical relevance of DLCOrb has not been evaluated. The aim of this study was to assess the feasibility of the rb method in children seen in a clinical setting and its relationships with sb method. SUBJECTS AND METHOD: We prospectively included children referred for 1) a suspected or confirmed interstitial lung d...
Source: Revue des Maladies Respiratoires - Category: Respiratory Medicine Tags: Rev Mal Respir Source Type: research
Aimmune Therapeutics Inc.'s quest to sell the first biologic drug to treat peanut allergies won a regulatory advisory committee's blessing Friday, moving the company closer to Food and Drug Administration approval. The action by the nine-member panel doesn't guarantee that the FDA will approve the drug, which would be branded as Palforzia, from Brisbane-based Aimmune (NASDAQ: AIMT). Advisory committee recommendations, however, typically hold great sway with the regulator. Palforzia is groundbreaking,…
Source: bizjournals.com Health Care:Pharmaceuticals headlines - Category: Pharmaceuticals Authors: Source Type: news
Publication date: Available online 15 September 2019Source: The LancetAuthor(s): Colin M Dayan, Maria Korah, Danijela Tatovic, Brian N Bundy, Kevan C HeroldSummaryOver several decades, studies have described the progression of autoimmune diabetes, from the first appearance of autoantibodies until, and after, the diagnosis of clinical disease with hyperglycaemia and insulin dependence. Despite the improved management of type 1 diabetes with exogenous insulin, most patients do not meet clinical glycaemic goals, and diabetes remains an important medical problem that affects children and adults. Clinical and preclinical studie...
Source: The Lancet - Category: General Medicine Source Type: research
Publication date: Available online 15 September 2019Source: The Lancet HIVAuthor(s): Joseph Kagaayi, Larry W Chang, Victor Ssempijja, M Kate Grabowski, Robert Ssekubugu, Gertrude Nakigozi, Godfrey Kigozi, David M Serwadda, Ronald H Gray, Fred Nalugoda, Nelson K Sew.ambo, Lisa Nelson, Lisa A Mills, Donna Kabatesi, Stella Alamo, Caitlin E Kennedy, Aaron A R Tobian, John S Santelli, Anna Mia Ekström, Helena NordenstedtSummaryBackgroundTargeting combination HIV interventions to locations and populations with high HIV burden is a global priority, but the impact of these strategies on HIV incidence is unclear. We assessed t...
Source: The Lancet HIV - Category: Infectious Diseases Source Type: research
Publication date: Available online 16 September 2019Source: Journal of Dental SciencesAuthor(s): Fang-yi Wu, Jeng-fen LiuAbstractBackground/purposeAsthma is a common, chronic disease that causes respiratory symptoms in children. Dental caries is also a common chronic disease in the pediatric population. Therefore, the aim of the present study was to investigate the correlation between asthma medications and dental caries among children in Taiwan.Materials and methodsThe Taiwan National Health Insurance Research Database was used in this retrospective cohort study to analyze the correlation between asthma and dental caries ...
Source: Journal of Dental Sciences - Category: Dentistry Source Type: research
An FDA advisory panel recommended peanut allergen powder (Palforzia, Aimmune Therapeutics) for children aged 4 years through 17 years who are allergic to peanuts.Medscape Medical News
Source: Medscape Medical News Headlines - Category: Consumer Health News Tags: Allergy & Clinical Immunology News Source Type: news
Alison Morris is the Division Chief, Pulmonary, Allergy and Critical Care Medicine, at the University of Pittsburgh Department of Medicine.
Source: bizjournals.com Health Care:Pharmaceuticals headlines - Category: Pharmaceuticals Authors: Source Type: news
Hadlima (adalimumab-bwwd), which is biosimilar to adalimumab, is now FDA approved to treat multiple autoimmune diseases...
Source: The Rheumatologist - Category: Rheumatology Authors: Tags: Biologics & Biosimilars Drug Updates adalimumab-bwwd FDA FDA approval Hadlima U.S. Food and Drug Administration (FDA) Source Type: research
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