Autoimmunity in Common Variable Immunodeficiency.
CONCLUSION: Mechanisms producing these conditions are poorly understood but include cytokine and cellular inflammatory pathways, and loss of tolerance to self-antigens through the multiple signaling molecules and pathways common to tolerance and immune deficiency. PMID: 31349011 [PubMed - as supplied by publisher]
This article reviews the phenotypes/endotypes of asthma described in India and the current therapies for management. PMID: 32738847 [PubMed - as supplied by publisher]
Conclusions: Cough is the most frequent presenting complaint in general practice. Infections are the most frequent causes of acute cough regardless of the chest X-ray findings. PMID: 32736491 [PubMed - as supplied by publisher]
What strategies may help reduce the incidence of healthcare-associated respiratory viral infections? Which are most effective?Current Opinion in Infectious Diseases
CONCLUSION: miR-182-5p mimic therapy inhibits the pathogenic Th17 response in EAU mice. miR-182-5p's inhibition of TAF15 negatively regulates Th17 cell development by suppressing STAT3 phosphorylation. As TAF15 shows a positive relationship with Th17 cell markers in uveitis patients, the miR-182-5p/TAF15 axis shows promise as a therapeutic target for uveitis. PMID: 32736708 [PubMed - as supplied by publisher]
ConclusionAlthough the immunological and clinical associations between EIMs and CD cannot be fully elucidated, identifying specific relationships of immune-mediated diseases will help to better understand CD pathogenesis.
AbstractPurpose of reviewA variety of skin diseases are associated with impaired barrier function. The crucial pillars in therapy of previously mentioned conditions are avoidance of triggers, skin protection and individually adapted medical therapy. Until recently, besides of topical corticosteroids, the treatment options were limited. However, a variety of new therapies of skin barrier-related skin diseases became available over the last years. Our goal was to investigate new findings and treatment options in skin diseases with barrier dysfunction, emphasizing on contact dermatitis, hand eczema and atopic dermatitis.Recen...
Conclusion: We present the characteristics of AIH patients in Central China for the first time. Five microbial biomarkers, including Lachnospiraceae, Veillonella, Bacteroides, Roseburia, and Ruminococcaceae, achieved a high potential distinguishing AIH patients from HCs.
Publication date: Available online 2 July 2020Source: Clinical Lymphoma Myeloma and LeukemiaAuthor(s): Michael Rassner, Johannes Jung, Johanna Schneider, Ralph Wäsch, Monika Engelhardt
Publication date: Available online 1 August 2020Source: The Journal of Allergy and Clinical Immunology: In PracticeAuthor(s): Liat Nachshon, Naama Schwartz, Lior Tsviban, Michael B. Levy, Michael Goldberg, Naama Epstein-Rigby, Yitzhak Katz, Arnon Elizur
Publication date: Available online 18 July 2020Source: The Journal of Allergy and Clinical Immunology: In PracticeAuthor(s): Allison Ramsey, S. Shahzad Mustafa