microRNA dysregulation in neurodegenerative diseases: A systematic review

Publication date: Available online 26 July 2019Source: Progress in NeurobiologyAuthor(s): Camille A. Juźwik, Sienna S. Drake, Yang Zhang, Nicolas Paradis-Isler, Alexandra Sylvester, Alexandre Amar-Zifkin, Chelsea Douglas, Barbara Morquette, Craig S. Moore, Alyson FournierAbstractWhile the root causes for individual neurodegenerative diseases are distinct, many shared pathological features and mechanisms contribute to neurodegeneration across diseases. Altered levels of microRNAs, small non-coding RNAs involved in post transcriptional regulation of gene expression, are reported for numerous neurodegenerative diseases. Yet, comparison between diseases to uncover commonly dysregulated microRNAs during neurodegeneration in general is lagging. We performed a systematic review of peer-reviewed publications describing differential microRNA expression in neurodegenerative diseases and related animal models. We compiled the results from studies covering the prevalent neurodegenerative diseases in the literature: Alzheimer’s disease, amyotrophic lateral sclerosis, aged-macular degeneration, ataxia, dementia, myotonic dystrophy, epilepsy, glaucoma, Huntington’s disease, multiple sclerosis, Parkinson’s disease, and prion disorders. MicroRNAs which were dysregulated most often in these diseases and their models included miR-9-5p, miR-21-5p, the miR-29 family, miR-132-3p, miR-124-3p, miR-146a-5p, miR-155-5p, and miR-223-3p. Common pathways targeted by these predominant m...
Source: Progress in Neurobiology - Category: Neuroscience Source Type: research

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CONCLUSIONS: This study described the characteristic of CG, number of its nerve root and some measurements relevant to intraorbital procedures in Asian population. Moreover, a new parameter was the distance between CG and scleral insertion of the lateral rectus muscle. This parameter should be considered when performing operation involved the lateral rectus muscle and BTX-A injection to lateral rectus muscle to reduce CG injury. PMID: 31621056 [PubMed - as supplied by publisher]
Source: Folia Morphologica - Category: Anatomy Tags: Folia Morphol (Warsz) Source Type: research
Publication date: Available online 17 October 2019Source: Physiology &BehaviorAuthor(s): Janelle A Skinner, Manohar L Garg, Christopher V Dayas, Tracy L BurrowsABSTRACTThe neuropeptide oxytocin is best known for its role during parturition and the milk-let down reflex. Recent evidence identifies a role for oxytocin in eating behaviour. After oxytocin administration, caloric intake is reduced with stronger inhibitory effects in individuals with obesity. Whether the experience of visual food cues affects secretion or circulating levels of oxytocin is unknown. This pilot study had three aims: 1) to measure fasting appetit...
Source: Physiology and Behavior - Category: Physiology Source Type: research
This study examined whether a history of traumatic brain injury (TBI) is associated with age at onset of Alzheimer's disease (AD) in three racial-ethnic groups. METHODS: Data from 7,577 non-Hispanic Caucasian, 792 African American, and 870 Hispanic participants with clinically diagnosed AD were obtained from the National Alzheimer's Coordinating Center. Participants were categorized by the presence or absence of self-reported remote history of TBI (>1 year before diagnosis of AD) with loss of consciousness (LOC) (TBI+) or no history of TBI with LOC (TBI-). Any group differences in education; sex; APOE ε4 all...
Source: Journal of Neuropsychiatry and Clinical Neurosciences - Category: Psychiatry Tags: J Neuropsychiatry Clin Neurosci Source Type: research
Predicting incident dementia 3-8 years after brief cognitive tests in the UK Biobank prospective study of 500,000 people. Alzheimers Dement. 2019 Oct 13;: Authors: Calvin CM, Wilkinson T, Starr JM, Sudlow C, Hagenaars SP, Harris SE, Schnier C, Davies G, Fawns-Ritchie C, Gale CR, Gallacher J, Deary IJ Abstract INTRODUCTION: Prospective studies reporting associations between cognitive performance and subsequent incident dementia have been subject to attrition bias. Furthermore, the extent to which established risk factors account for such associations requires further elucidation. METHODS: We us...
Source: The Journal of Alzheimers Association - Category: Psychiatry Tags: Alzheimers Dement Source Type: research
Publication date: Available online 17 October 2019Source: Molecular Genetics and MetabolismAuthor(s): Antony Cougnoux, Mason Fellmeth, Tansy Gu, Cristin D. Davidson, Alana L. Gibson, William J. Pavan, Forbes D. PorterAbstractNiemann-Pick disease, type C1 (NPC1) is a rare neurodegenerative lysosomal storage disease with a wide spectrum of clinical manifestation. Multiple genetic factors influence the NPC1 mouse phenotype, but very little attention has been given to prenatal environmental factors that might have long-term effects on the neuroinflammatory component of NPC1 pathology. Studies in other mouse models of cerebella...
Source: Molecular Genetics and Metabolism - Category: Genetics & Stem Cells Source Type: research
ConclusionsMildly elevated tau-PET binding was observed in a subset of amyloid-negative patients at risk for CTE, in a distribution consistent with CTE pathology stages III-IV. FTP-PET may be useful as a biomarker of tau pathology in CTE but is unlikely to be sensitive to early disease stages.
Source: NeuroImage: Clinical - Category: Radiology Source Type: research
Publication date: Available online 17 October 2019Source: NeuroImage: ClinicalAuthor(s): Barbara A.K. Kreilkamp, Lucy Lisanti, G. Russell Glenn, Udo C. Wieshmann, Kumar Das, Anthony G. Marson, Simon S. KellerAbstractObjectiveTo investigate the agreement between manually and automatically generated tracts from diffusion tensor imaging (DTI) in patients with temporal lobe epilepsy (TLE). Whole and along-the-tract diffusivity metrics and correlations with patient clinical characteristics were analyzed with respect to tractography approach.MethodsWe recruited 40 healthy controls and 24 patients with TLE who underwent conventio...
Source: NeuroImage: Clinical - Category: Radiology Source Type: research
ConclusionsIn our study cohort, early surgery for PFV achieved functional visual acuity in about one-third of patients. Limbal approach to surgery may result in better visual acuity and anatomic results.
Source: Journal of American Association for Pediatric Ophthalmology and Strabismus - Category: Opthalmology Source Type: research
ConclusionWhile openness and aesthetic interests differ greatly between PNES and ES groups, low sensitivity and specificity suggests their use is limited in a clinical setting. Nevertheless, these findings open up new avenues of research using modern personality models to further understand patients with epilepsy and related presentations.
Source: Seizure - Category: Neurology Source Type: research
Conclusionsanti-TG6 do not seem to be associated to epilepsies with cerebral calcifications.
Source: Seizure - Category: Neurology Source Type: research
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