Sarcoendoplasmic Reticulum Calcium Transport ATPase 2a: A Potential Gene Therapy Target in Heart Failure

The development of cardiac-specific adeno-associated viral vectors capable of long-term transgenic expression has opened new avenues in the therapeutic approach to heart failure. Failing cardiomyocytes demonstrate altered calcium-handling secondary to depressed expression and activity of myocardial sarcoendoplasmic reticulum calcium ATPase 2a (SERCA2a). This observation has led to a large body of research investigating the therapeutic utility of SERCA2a gene therapy in heart failure.
Source: Cardiology in Review - Category: Cardiology Tags: Review Article Source Type: research