Serine protease inhibitors and activators from Dalbergia tonkinensis species
AbstractThe vulnerable plantDalbergia tonkinensis Prain is a rare species in Vietnam. In the course of our studies on biologically active plants, we performed serine protease enzyme screenings. The results suggest that at concentrations of 25 –250 ng/mL, methanol extracts of leaf and root, root ethanol extract and its dichloromethane fraction, and heartwood water decoction extract can serve as useful sources to stimulate trypsin enzyme activity. In addition, water decoction extracts of leaf and stem bark may explain unknown ethno-phar macology due to the high inhibitory effects in enzyme assays using trypsin, chymotrypsin, and elastase. Among 23 isolated compounds and two semi-synthetic derivatives tested, quercetin (17) inhibits the activities of trypsin and chymotrypsin with IC50 9.7 µM. Flavonoids categorized as flavanone, isoflavanone, flavone, isoflavone, pretocarpan, aurone, and neoflavanone demonstrated variable activities. Several substitutions are closely correlated with protease actions, including hydroxylation at C-3 and C-3′ in flavone and C-5 and C-3′ in isofla vone, hydroxylation at C-3, C-5 and C-3′, carboxylation at C-6 and C-8, and 7-substitution in flavanone; 7-substitution and methoxylation at C-3′ in isoflavanone; and lactone ring opening in neoflavanone. In the assessment of casein cleavage, at a dose of 25 ng/mL, leaf water decoction extract demonstrates an inhibitory effect on casein cleavage by trypsi...
Authors: Hanewinkel R PMID: 31623003 [PubMed - in process]
Zum Kommentar von Prof. Reiner Hanewinkel zum Hot Topic-Thema „Raucherentwöhnung: E-Zigarette besser als klassische Nikotinersatzpräparate?“ Pneumologie 2019; 73: 336 – 337. Pneumologie. 2019 Oct;73(10):622 Authors: Pommer P PMID: 31623002 [PubMed - in process]
Authors: Schulz H, Karrasch S, Bölke G, Cyrys J, Hornberg C, Pickford R, Schneider A, Witt C, Hoffmann B PMID: 31623001 [PubMed - in process]
Leserbrief zu Schulz H, Karrasch S, Bölke G et al. Atmen: Luftschadstoffe und Gesundheit – Teil I. Pneumologie 2019; 73: 288 – 305. Pneumologie. 2019 Oct;73(10):617-619 Authors: Schnitzler A PMID: 31623000 [PubMed - in process]
Authors: Schöll N, Rohde GGU Abstract Pneumonia belongs to the most frequent and most deadly infectious diseases worldwide. It represents an increasing problem for the aging population. The incidence and mortality rises with every decade. The clinical presentation of pneumonia differs between elderly and younger patients. Multiple factors including functional status (self-dependency and immobilization), comorbidities, immunosenescence, nutritional status, swallowing disorders have to be accounted for. Pneumonia in the elderly has to be differentiated from nursing home acquired pneumonia. Diagnosis of pneumonia...
Perikardpunktion – Schritt für Schritt. Pneumologie. 2019 Oct;73(10):597-604 Authors: Ferrari MW PMID: 31622998 [PubMed - in process]
Authors: Raspe M, Rolling T, Leisse C, Fischer J, Lehmann C Abstract Infectious Diseases are a cross-sectional area connected to various medical disciplines and offer interested physicians multiple working opportunities. The spectrum of infectious diseases covers both out- and inpatient care as well as basic, clinical and epidemiological research. The need for infectious diseases specialists is increasing, thus career prospects are promising. Working conditions in infectious diseases are comparatively family-friendly. With this article we intend to arouse interest for working in the fascinating fields of infectious...
Authors: Bahmer T, Wälscher J, Fisser C, Kreuter M, Karg O, Böing S, Koczulla R, Raspe M PMID: 31622996 [PubMed - in process]
Lungengesundheit: Beruf als großer Risikofaktor? Pneumologie. 2019 Sep;73(9):e2 Authors: Simon A PMID: 31622984 [PubMed - in process]
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