Clinical outcomes after colchicine overdose: A case report

Rationale: Colchicine can inhibit cell division and intracellular transport in affected organs by fixing intracellular tubulin and preventing its polymerization into microtubules. A lethal dose of colchicine is considered to be 0.8 mg/kg. The wide distribution of colchicine through 70% of the body following an overdose makes it difficult to eliminate. Patient concerns: A 56-year-old man with a clear history of colchicine overdose was admitted to our hospital nearly 40 hours after taking 12 mg (0.17 mg/kg) of colchicine. He had a history of gout and chronic kidney disease. As the disease progressed, he showed most of the clinical manifestations and pathological features of colchicine overdose. Diagnoses and interventions: Colchicine overdose was clear, with symptoms of multiple organ failure including primary gastrointestinal failure, bone marrow hematopoietic inhibition, rhabdomyolysis, cardiac damage, hepatocyte damage. The patient developed secondary septic shock, renal failure, circulatory failure, and respiratory failure. We performed continuous renal replacement therapy and gastric lavage, and administered norepinephrine, frozen plasma, proton-pump inhibitors, adenosylmethionine, antibiotics, granulocyte colony stimulating factor, and total parenteral nutrition. Outcomes: The patient rapidly developed complete hematopoietic function inhibition, gastrointestinal failure, and cardiac damage 32 hours after admission. Sustained severe infection and circu...
Source: Medicine - Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research

Related Links:

Authors: Verhoestraete P, Marijn C, Jan D, Hans V PMID: 31536463 [PubMed - as supplied by publisher]
Source: Acta Cardiologica - Category: Cardiology Tags: Acta Cardiol Source Type: research
(Reuters Health) - Behavior changes could potentially reduce a large part of the risk for developing gout, a U.S. study suggests.
Source: Reuters: Health - Category: Consumer Health News Tags: healthNews Source Type: news
Medgadget has previously reported on Abbott’s FreeStyle Libre 14 day system, most recently when we interviewed them at CES 2019. The company has aimed to help people with diabetes move away from traditional fingerstick testing towards continuou...
Source: Medgadget - Category: Medical Devices Authors: Tags: Exclusive Medicine Source Type: blogs
Conclusion: Renal allograft damage caused by BKVN involved T lymphocyte-, B lymphocyte- and mononuclear macrophage-mediated immune responses. Inflammatory cell infiltrations in the renal allograft were probably the driving force for BKVN progression. Additionally, eosinophils and neutrophils may be involved in the pathophysiological mechanism of BKVN. PMID: 31535918 [PubMed - in process]
Source: Renal Failure - Category: Urology & Nephrology Tags: Ren Fail Source Type: research
Publication date: Available online 19 September 2019Source: Journal of Food EngineeringAuthor(s): Zahra Moaddabdoost Baboli, Leonard Williams, Guibing ChenAbstractJuices are usually thermally pasteurized, but high temperatures negatively affect their nutritional and sensory qualities. For this reason, nonthermal pasteurization techniques with little or no heat applied have been developed to minimize the quality losses. Among them, high-intensity ultrasound has been considered as a promising technique for juice pasteurization. Despite the extensive studies, a long pasteurization time is needed to achieve the required 5-log ...
Source: Journal of Food Engineering - Category: Food Science Source Type: research
Publication date: Available online 18 September 2019Source: Molecular and Biochemical ParasitologyAuthor(s): Alba Cortés, Laura Peachey, Riccardo Scotti, Timothy P Jenkins, Cinzia CantacessiAbstractThe gastrointestinal (GI) tract of vertebrates is inhabited by a vast array of organisms, that is, the microbiota and macrobiota. The former is composed largely of commensal microorganisms, which play vital roles in host nutrition and maintenance of energy balance, in addition to supporting the development and function of the vertebrate immune system. By contrast, the macrobiota includes parasitic helminths, which are mos...
Source: Molecular and Biochemical Parasitology - Category: Parasitology Source Type: research
Authors: Rossi M, Delbauve S, Roumeguère T, Wespes E, Leo O, Flamand V, Le Moine A, Hougardy JM Abstract Ischemia-reperfusion injury (IRI) is a leading cause of acute kidney injury (AKI), which contributes to the development of chronic kidney disease (CKD). IRI-induced AKI releases proinflammatory cytokines (e.g. IL-1β, TNF-α, IL-6) that induce a systemic inflammatory response, resulting in proinflammatory cells recruitment and remote organ damage. AKI is associated with poor outcomes, particularly when extrarenal complications or distant organ injuries occur. Acute lung injury (ALI) is a major re...
Source: Free Radical Research - Category: Research Tags: Free Radic Res Source Type: research
Guideline-changing trial results released earlier in 2019 suggest that SGLT2 inhibitors could be a viable treatment solution for patients with diabetes and evidence of kidney damage.
Source: The Pharmaceutical Journal - Category: Drugs & Pharmacology Source Type: research
This study is the first report of K. ogawai infection in cultured olive flounder in Korea. PMID: 31533413 [PubMed - in process]
Source: Korean Journal of Parasitology - Category: Parasitology Tags: Korean J Parasitol Source Type: research
Authors: Licata C, Liu L, Mole D, Thorp J, Chand R, Chaulagain S Abstract Organophosphates are commonly used in rural, agricultural communities worldwide. Poisoning in Nepal is commonly a result of suicide attempt via ingestion with a mortality rate of 41 times higher than in the United States even after appropriate treatment. The patient discussed in this case is a 46-year-old Nepalese female with a complicated psychosocial history that presented with a suicide attempt via organophosphate ingestion. She required higher doses and greater lengths of treatment of atropine and pralidoxime to resolve symptoms of toxici...
Source: Case Reports in Psychiatry - Category: Psychiatry Tags: Case Rep Psychiatry Source Type: research
More News: Chronic Kidney Disease | Colchicine | Colcrys | Gastric Lavage | Gastroenterology | Gout | Hospitals | Internal Medicine | Lessons | Liver | Nutrition | Overdose | Parenteral Nutrition | Poisoning | Renal Failure | Respiratory Medicine | Rhabdomyolysis | Septic Shock | Urology & Nephrology