Binding to carboxypeptidase M mediates protective effects of fibrinopeptide B β(15-42)

During fibrinolysis a 28 amino acid peptide is generated besides other degradation products of fibrin. This peptide, called B β15–42, which is cleaved by plasmin from the end of the fibrin Bβ-chain, is protective in myocardial and renal ischemia/reperfusion injury and improves the outcome in experimental sepsis. Bβ15–42 has been shown to mediate different beneficial effects in endothelial cells through binding to va scular endothelial-cadherin. Here, we provide in vitro and in vivo evidence that Bβ15–42 has additional cell protective activity in tubular cells, which is caused by a distinct mechanism.

Source: Translational Research - July 25, 2019 Category: Research Authors: Inga S örensen-Zender, Rongjun Chen, Rong Song, Sascha David, Anette Melk, Hermann Haller, Roland Schmitt Source Type: research